银杏叶片联合地塞米松治疗神经性耳鸣的临床疗效研究  

Clinical study of ginkgo tablets combined with dexamethasone in the treatment of nervous tinnitus

作　　者：林高贵 LIN Gao-gui(Department of Otolaryngology,Guantou Town Central Hospital of Lianjiang County,Fuzhou 350501,China)

机构地区：[1]福建省连江县琯头镇中心卫生院耳鼻喉科,350501

出　　处：《中国现代药物应用》2023年第9期32-35,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究银杏叶片联合地塞米松治疗神经性耳鸣的临床疗效。方法70例神经性耳鸣患者,按照随机数字表法分为对照组和观察组,各35例。对照组采取地塞米松治疗,观察组采取银杏叶片联合地塞米松治疗。比较两组患者临床疗效、不良反应发生率及治疗前后耳鸣情况(耳鸣致残量表评分、响度评分)、中枢神经递质[血清5-羟色胺(5-HT)和γ-氨基丁酸(GABA)]水平。结果观察组的治疗总有效率91.43%高于对照组的71.43%,差异有统计学意义(P<0.05)。治疗前,两组患者的耳鸣致残量表评分和响度评分比较,差异无统计学意义(P>0.05);治疗后,两组患者的耳鸣致残量表评分和响度评分均低于本组治疗前,且观察组患者的耳鸣致残量表评分(26.38±3.41)分和响度评分(5.24±1.26)分均低于对照组的(32.54±4.19)、(7.07±1.42)分,差异有统计学意义(P<0.05)。治疗前,两组患者的血清5-HT和GABA水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的血清5-HT水平低于本组治疗前,GABA水平高于本组治疗前,且观察组患者的血清5-HT(20.74±3.31)ng/L低于对照组的(27.56±3.85)ng/L,GABA(45.82±5.03)ng/L高于对照组的(33.69±4.48)ng/L,差异有统计学意义(P<0.05)。观察组患者的不良反应发生率为5.71%,与对照组的11.43%比较,差异无统计学意义(P>0.05)。结论银杏叶片联合地塞米松治疗神经性耳鸣的临床疗效显著,可有效改善耳鸣症状,使中枢神经递质水平得以恢复,治疗安全性也具有较高保障,是一种应用价值较高的用药方式,可以推广应用。Objective To investigate the clinical efficacy of ginkgo tablets combined with dexamethasone in the treatment of nervous tinnitus.Methods A total of 70 patients with nevous tinnitus were divided into control group and observation group according to the random numerical table,with 35 cases in each group.The control group was treated with dexamethasone,and the observation group was treated with ginkgo tablets and dexamethasone.Both groups were compared in terms of clinical efficacy,incidence of adverse reactions,tinnitus(tinnitus handicap inventory score,loudness score)and central neurotransmitter[serum 5-hydroxytryptamine(5-HT)and gamma-aminobutyric acid(GABA)]levels before and after treatment.Results The total effective rate of the observation group was 91.43%,which was higher than that of 71.43% of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in tinnitus handicap inventory score and loudness score between the two groups(P>0.05).After treatment,the tinnitus handicap inventory score and loudness score in the two groups were lower than those before treatment in this group;the tinnitus handicap inventory score of(26.38±3.41)points and loudness score of(5.24±1.26)points in the observation group were lower than those of(32.54±4.19)and(7.07±1.42)points in the control group;the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in serum 5-HT and GABA levels between the two groups(P>0.05).After treatment,the serum 5-HT level in the two groups was lower than that before treatment in this group,while GABA level was higher than that before treatment in this group;the serum 5-HT of(20.74±3.31)ng/L in the observation group was lower than that of(27.56±3.85)ng/L in the control group;GABA of(45.82±5.03)ng/L in the observation group was higher than that of(33.69±4.48)ng/L in the control group;the differences were statistically significant(P<0.05).The incidence

关 键 词：神经性耳鸣 银杏叶片 地塞米松 临床疗效 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]