补中益气汤的免疫药理及其临床应用研究进展  被引量:16

A review on immunopharmacological mechanism and clinical application of the Buzhong Yiqi decoction

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作  者:邓逸菲 李明达 刘端勇[1] 赵海梅[1] 周文 DENG Yifei

机构地区:[1]江西中医药大学,江西南昌330004 [2]南昌医学院,江西南昌330004

出  处:《中医临床研究》2023年第7期68-72,共5页Clinical Journal Of Chinese Medicine

基  金:省级大学生创新训练项目(202210412054);国家级大学生创新训练项目(202113437002);江西省教育厅科技计划项目(GJJ218903);江西省卫生健康委员会科技计划(SKJP_220211032)。

摘  要:补中益气汤是一首中医经典名方,出自于中国古代金元时期的著名医学家李杲(号东垣)的著作《内外伤辨惑论》。近年来发现补中益气汤具有良好的免疫调节作用,对炎症性肠病、过敏性紫癜、肌无力等免疫性疾病和癌症术后具有明显的治疗效果。该方立方严谨、疗效可靠,为补中益气、升阳举陷、健脾除热之要方,主治脾虚气陷证、气虚发热证,是“甘温除大热”的代表方剂。从现代医学角度看,其方具有良好的调节巨噬细胞、B细胞、T细胞、辅助性T细胞(Th17细胞)及调节性T细胞(Treg细胞)的药理作用,被广泛运用于各类自身免疫性疾病、癌症等免疫相关性疾病的预防和治疗。文章从补中益气汤的药理作用和临床应用两个方面对近年来的相关文献进行综述,为进一步促进该方药的临床合理应用和新药研发提供参考。按照中医“异病同治”理论,尽管其调控免疫的机制并不明朗,但正是因为其良好的治疗效果,故基于补中益气汤和调控免疫的新药研发虽任重道远,却也前景宽广。The Buzhong Yiqi decoction(补中益气汤)is a famous classic prescription of TCM,and comes from Neiwaishang Bianhuo Lun(《内外伤辨惑论》),which was written by LI Gao,a famous medical expert in the Jin and Yuan Dynasties in ancient China.In recent years,it has been found that the Buzhong Yiqi decoction has a good immunomodulatory effect,and has obvious therapeutic effects on immune diseases such as inflammatory bowel disease,Henoch-Schönlein purpura,myasthenia and cancer after surgery.The Buzhong Yiqi decoction is regarded as an important prescription for invigorating spleen-stomach and replenishing Qi(气),elevating Yang(阳)and raising the drooping,strengthening spleen and eliminating fever,which is a representative prescription of relieving fever with sweet and warm-natured drugs.The prescription is rigorous and has a reliable curative effect.As it has good pharmacological effects on regulating macrophages,B cells,T cells,Th17 cells,Treg cells,it can be widely used in the prevention and treatment of various autoimmune diseases,cancer and other immune related diseases.This paper reviews the relevant literatures in recent years from the respective of pharmacological effects and clinical application in order to provide a reference for further promoting rational clinical application of the Buzhong Yiqi decoction and new drug research and development.According to the theory of different diseases and treatment in TCM,although the mechanism of regulating immunity is not clear,it is precisely because of its good therapeutic effects that the research and development of new drugs based on the Buzhong Yiqi decoction and regulating immunity has a long way to go,but also has broad prospects.

关 键 词:补中益气汤 免疫药理 作用机制 中医理论 临床价值 

分 类 号:R289.5[医药卫生—方剂学]

 

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