H5亚型禽流感病毒的危害与疫苗研究进展  

Harm of Avian Influenza Virus H5 Subtype and Research Progress on Related Vaccines

作　　者：秦立得 孙荣钊[2,3] 马冬 宋翠平 田文霞[1] Qin Lide;Sun Rongzhao;Ma Dong;Song Cuiping;Tian Wenxia(Shanxi Agricultural University,Taiyuan,Shanxi 030031,China;China Animal Health and Epidemiology Center,Qingdao,Shandong 266032,China;Northeast Agricultural University,Harbin,Heilongjiang 150006,China;Qingdao Yebio Bioengineering Co.,Ltd.,Qingdao,Shandong 266032,China)

机构地区：[1]山西农业大学,山西太原030031 [2]中国动物卫生与流行病学中心,山东青岛266032 [3]东北农业大学,黑龙江哈尔滨150006 [4]青岛易邦生物工程有限公司,山东青岛266032

出　　处：《中国动物检疫》2023年第5期55-60,共6页China Animal Health Inspection

基　　金：山西省重点研发计划项目(202102130501001);中美新发和再发传染病合作项目(E090090201-3,E2900901-02);山西省现代农业产业技术体系建设专项;山西省1331工程项目(20211331-13);山西省科技创新青年人才团队项目。

摘　　要：H5亚型禽流感病毒(AIV)在全球范围内的广泛传播,对禽类养殖业健康发展与公共卫生安全都造成了巨大威胁。本文阐明了以H5N1、H5N6、H5N8亚型为代表的H5亚型AIV引发的国内外多起家禽和野鸟疫情,使家禽养殖业蒙受严重损失,且H5亚型AIV易变异和重组的特点,增加了疫情防控难度,同时也极易引发跨越物种屏障向人传播事件,危害公共卫生安全等问题;系统阐述了灭活疫苗等不同种类AIV疫苗的研发进展,强调了当前灭活疫苗应用最为广泛,但亚单位疫苗、DNA疫苗、多肽疫苗等新型疫苗正日益获得关注。本文以期为禽流感疫情暴发预警,“同一健康”理念宣贯,以及疫苗研发提供理论支持。Avian influenza virus H5 subtype(AIV-H5)is widely spreading in the world,posing a huge threat to poultry industry and public health.The industry was seriously damaged by several global outbreaks in domestic poultry and wild birds caused by AIV-H5 represented by H5N1,H5N6 and H5N8 virus.In addition,AIV-H5 was prone to mutation and recombination,which not only increased the difficulty of disease prevention and control,but also easily lead to incidents of transmission across species barriers to human,endangering public health and safety and other issues;research progress on different types of AIV vaccines such as inactivated vaccines was systematically described,emphasizing that current inactivated vaccines were predominant,but new vaccines such as subunit vaccines,DNA vaccines and peptide vaccines were emerging.A theoretical support was provided by the paper for early warning of avian influenza outbreaks,the promotion of“One Health”concept and for vaccine researches.

关 键 词：禽流感 公共卫生 家禽养殖 预警监测 疫苗研究 

分 类 号：S851.3[农业科学—预防兽医学]