三种猪用疫苗联合免疫的可行性分析  

Feasibility Analysis of Combined Immunization with Three Kinds of Swine Vaccines

作　　者：陈昌海[1] 连拯民 邱冬 宋晓莉 开妍[1] 李向东 王相子[1] 邵坤 朱心访 CHEN Chang-hai;LIAN Zheng-min;QIU Dong;SONG Xiao-li;KAI Yan;LI Xiang-dong;WANG Xiang-zi;SHAO Kun;ZHU Xin-fang(Jiangsu Provincial Animal Disease Control Center,Nanjing 210036,China;College of Veterinary Medicine,Yangzhou University,Yangzhou,Jiangsu 225009,China;Xuyi Animal Disease Control Center,Huaian,Jiangsu 211700,China;Wenshi Food Group Co.,Ltd.Jiangsu Pig Farming Company,Huaian,Jiangsu 223001,China)

机构地区：[1]江苏省动物疫病预防控制中心,南京210036 [2]扬州大学兽医学院,江苏扬州225009 [3]盱眙县动物疫病预防控制中心,江苏淮安211700 [4]温氏食品集团股份有限公司江苏养猪公司,江苏淮安223001

出　　处：《中国兽药杂志》2023年第5期6-12,共7页Chinese Journal of Veterinary Drug

基　　金：江苏现代农业(生猪)产业技术体系疾病防控创新团队(JATS【2021】358)。

摘　　要：为简化免疫程序,减少免疫次数,降低反复多次免疫对猪只的应激,采用三种猪用疫苗联合免疫进行可行性分析。首先将猪瘟、猪丹毒、猪多杀性巴氏杆菌病三联活疫苗与猪伪狂犬病活疫苗进行混合,测定了混合后猪瘟病毒、伪狂犬病病毒、猪丹毒杆菌和多杀性巴氏杆菌的活性。同时,在试验猪群中开展混合疫苗与猪圆环病毒2型灭活疫苗同步两点注射的联合免疫效果评价。结果显示,三联活疫苗和猪伪狂犬病活疫苗的混合疫苗与猪圆环病毒2型灭活苗的联合免疫不会降低疫苗的免疫效果,且能够达到较单独免疫更好的免疫效果,表明采用三种猪用疫苗进行联合免疫是完全可行的。In order to simplify the immunization procedure,reduce the frequency of immunizations,and reduce the stress response caused by multiple immunizations,three kinds of swine vaccines were used for combined immunization to carry out feasibility analysis.First,the combined classical swine fever,swine erysipelas and Pasteurella multocida live vaccine was mixed with swine pseudorabies live vaccine,and the activities of the combined classical swine fever virus,pseudorabies virus,and Erysipelothrix rhusiopathiae and Pasteurella multocida were measured.At the same time,the evaluation of immune effect on the two-point simultaneous injection of combined vaccines and porcine circovirus type 2 inactivated vaccine was performed on pigs.The results showed that the immune effect of classical swine fever,swine erysipelas and Pasteurella multocida live vaccine,swine pseudorabies live vaccine and porcine circovirus type 2 inactivated vaccine was not weakened by combined immunization.And it was more effective than respective immunization of three vaccines.This indicates that the use of three swine vaccines for combined immunization is completely feasible.

关 键 词：猪瘟、猪丹毒、猪多杀性巴氏杆菌病三联活疫苗 猪伪狂犬病活疫苗 猪圆环病毒2型灭活疫苗 联合免疫效果 

分 类 号：S859.797[农业科学—临床兽医学]