非洲马瘟病毒VP7蛋白研究进展  

Research Progress on VP7 Protein of African Horse Sickness Virus

作　　者：张桂铭 张兵[1] 张敏[1] 宋亚芬 王磊[1] 杨承槐[1] ZHANG Gui-ming;ZHANG Bing;ZHANG Min;SONG Ya-fen;WANG Lei;YANG Cheng-huai(China Institute of Veterinary Drug Control,Beijing 100081,China)

机构地区：[1]中国兽医药品监察所,北京100081

出　　处：《中国兽药杂志》2023年第5期87-94,共8页Chinese Journal of Veterinary Drug

基　　金：“十四五”国家重点研发计划“重大外来动物疫病阻断与防控技术研发项目”(2022YFD1800500);兽药行业公益性重点专项“非洲马瘟病毒毒种研究”(GY202030)。

摘　　要：非洲马瘟(African horse sickness, AHS)是由非洲马瘟病毒(African horse sickness virus, AHSV)引起的一种通过库蜢等昆虫传播的、主要感染马科动物的传染病。我国是世界动物卫生组织认可的非洲马瘟无疫国,随着AHS疫情在东南亚的传播,增大了疫情传入我国的风险。AHSV编码了7种结构蛋白(VP1~VP7),其中VP7是病毒内衣壳蛋白的主要组成部分,在AHSV 9个血清型中高度保守,常作检测的靶标。此外,VP7蛋白的自组装特点对于AHSV亚单位疫苗和病毒样颗粒疫苗(VLP)的研究有基础性作用。对当前AHSV VP7蛋白相关研究进展进行了综述,以期为AHSV检测方法及疫苗等研究提供参考。African horse sickness(AHS)is an infectious disease caused by African horse sickness virus(AHSV),which mainly infects equines and is transmitted by insects such as Culicoides.Our country is an African horse sickness-free country recognized by the World Organization for Animal Health(WOAH).With the spread of the African horse sickness in Southeast Asia,the risk of the epidemic spreading to our country has increased.AHSV encodes 7 structural proteins(VP1~VP7),among which VP7 is the main component of the inner capsid protein,which is highly conserved in the 9 serotypes of AHSV and is often used as a target for detection.In addition,the self-assembly of VP7 protein has a fundamental role in the research of AHSV subunit vaccine and virus-like particle(VLP)vaccine.This article reviews the current progress of AHSV VP7 protein research in order to provide references for AHSV detection methods and vaccine research.

关 键 词：AHSV VP7 结构 诊断 疫苗 

分 类 号：S852.65[农业科学—基础兽医学]