运动介导外泌体miRNA防治2型糖尿病合并肌少症的研究进展  

Research progress of exercise-mediated exosomes miRNA in the preven⁃tion and treatment of type 2 diabetes mellitus with sarcopenia

作　　者：邹琪 刘军[2] 孙晓敏 ZOU Qi;LIU Jun;SUN Xiaomin(Graduate Faculty,Xi'an Physical Education University,Xi'an 710068,China;College of Sports and Health Sciences,Xi'an Physical Education University,Xi'an 710068,China;Global Health Institute,School of Public Health,Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安体育学院研究生部,陕西西安710068 [2]西安体育学院运动与健康科学学院,陕西西安710068 [3]西安交通大学公共卫生学院和全球健康研究院,陕西西安710061

出　　处：《中国病理生理杂志》2023年第5期919-927,共9页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81703220)。

摘　　要：糖尿病是以高血糖为特征的慢性代谢性疾病,据2 021年国际糖尿病联盟数据,预计2 045年全球糖尿病患者人数将增至7.83亿人,中国患者将增至1.75亿,其中90%为2型糖尿病(type 2 diabetes mellitus,T2DM)[1]。肌少症(sarcopenia),是一种与年龄相关的肌肉质量下降和功能丧失的老年综合征,在T2DM患者中发病率已达21%,患者发生跌倒、骨折、残疾的风险显著增高[2]。Type 2 diabetes mellitus(T2DM)is a prevalent metabolic disorder that can lead to muscle atro⁃phy.The characteristics of T2DM with sarcopenia including a loss of muscle mass,decrease of muscle strength,and func⁃tion dampened with progress.This debilitating condition decrease the quality of life of patients.Therefore,exploring the pathogenesis of T2DM with sarcopenia is crucial for its prevention and treatment.Recently,it has been found that exo⁃somes(EXs)are involves in the proliferation and differentiation of skeletal muscle but also mediates the exchange of infor⁃mation between skeletal muscle and other tissue organs.Exercise is also known to be an effective way to regulate blood glu⁃cose levels and improve muscle mass and strength.Exercise stimulate the release of EXs and their accompanying microR⁃NA(miRNA),which may help to slow down the progression of T2DM with sarcopenia.The purpose of this article is to re⁃view the pathogenesis of T2DM with sarcopenia by the potential ways in which exercise-induced EXs miRNA would have beneficial on this condition.This review may provide references for the exercise in preventing and treating T2DM with sar⁃copenia.

关 键 词：外泌体 微小RNA 2型糖尿病 肌少症 运动 

分 类 号：R587.1[医药卫生—内分泌] R363.2[医药卫生—内科学]