多囊卵巢综合征脂代谢异常的病例对照研究  

Dyslipidaemia in polycystic ovarian syndrome patients:a case-control study

作　　者：周嘉禾 缪华章[2] 钟明琳 李远成 王友烽 范明皓 邱琳 李荔[1,2] Zhou Jiahe;Miao Huazhang;Zhong Minglin(Guangzhou Medical University,Guangzhou510000;Guangdong Women and Children Hospital,Guangzhou511442)

机构地区：[1]广州医科大学,广州510000 [2]广东省妇幼保健院,广州511442 [3]澳门科技大学,中国澳门000853

出　　处：《现代妇产科进展》2023年第5期365-368,372,共5页Progress in Obstetrics and Gynecology

基　　金：广东省自然科学基金资助项目(No:2021A1515010763);广东省国际及港澳台高端人才交流专项(No:174007);澳门特别行政区科学技术发展基金(No:0048/2021/A1)。

摘　　要：目的:分析多囊卵巢综合征(PCOS)脂代谢紊乱的危险因素,为PCOS远期并发症的筛查、治疗、预防提供临床指导。方法:收集就诊于广东省妇幼保健院413例PCOS患者临床资料,分析PCOS患者高脂血症的危险因素。结果:Logistic回归分析显示,年龄(OR=1.681,95%CI为1.047~2.699)、多毛评分(OR=1.912,95%CI为1.165~3.137)、体质量指数(BMI)(OR=2.474,95%CI为1.420~4.310)、黄体生成素/卵泡刺激素比值(LH/FSH)(OR=3.779,95%CI为2.127~6.711)、抗苗勒管激素(AMH)(OR=2.307,95%CI为1.195~4.456)、游离睾酮指数(FAI)(OR=1.890,95%CI为1.092~3.271)是PCOS患者高脂血症的独立危险因素(均P<0.05)。相关性分析显示,PCOS患者血清甘油三酯(TG)与FAI呈正相关(R=0.145,P=0.003),总胆固醇(TC)与AMH呈正相关(R=0.129,P=0.009),低密度脂蛋白(LDL)与LH/FSH、FAI呈正相关(R=0.078,P=0.048;R=0.121,P=0.013)。结论:年龄、超重、高雄激素、高LH/FSH和高AMH是PCOS患者发生高脂血症的独立危险因素。PCOS患者的血脂水平升高,与LH/FSH、AMH、FAI呈正相关。Objective:To investigate the risk factors of hyperlipidemia in polycystic ovary syndrome(PCOS),and to provide guidance for clinical screening,management and precaution for PCOS long-term complications.Methods:Four hundred and thirteen patients from Guangdong Women and Children Hospital were collected,to analyze the risk factors for hyperlipidemia in PCOS patients.Results:Logistic regression analysis showed that age(OR=1.681,95%CI 1.047~2.699),hirsutism(OR=1.912,95%CI 1.165~3.137),body mass index(BMI)(OR=2.474,95%CI 1.420~4.310),luteinizing hormone/follicle stimulating hormone(LH/FSH)(OR=3.779,95%CI 2.127~6.711),anti-mullerian hormone(AMH)(OR=2.307,95%CI 1.195~4.456),free testosterone index(OR=1.890,95%CI 1.092~3.271)were independent risk factors for hyperlipidemia in PCOS patients(all P<0.05).Correlation analysis demonstrated that significant positive correlation were found between serum triglyceride(TG)and FAI(R=0.145,P=0.003),total cholesterol(TC)and AMH(R=0.129,P=0.009),low density lipoprotein(LDL)and LH/FSH,FAI(R=0.078,P=0.048;R=0.121,P=0.013).Conclusions:Age,overweight,high androgen,high LH/FSH and high AMH are the independent risk factors for hyperlipidemia in PCOS patients.PCOS patients have elevated levels of serum lipids and positively correlated with LH/FSH,AMH and FAI.

关 键 词：多囊卵巢综合征 高脂血症 高雄激素血症 抗苗勒管激素 不孕 

分 类 号：R711[医药卫生—妇产科学]