Annulohypoxylon stygium,a Pandanus simplex-associated fungal endophyte withα-glucosidase inhibitory activity  

作　　者：Roberth Riggs L.Rondilla Thomas Edison E.dela Cruz Fang-Rong Chang Maribel G.Nonato 

机构地区：[1]The Graduate School,University of Santo Tomas,España Blvd.1015 Manila,Philippines [2]Research Center for the Natural and Applied Sciences,University of Santo Tomas,España Blvd.1015 Manila,Philippines [3]Department of Biological Sciences,College of Science,University of Santo Tomas,España Blvd.1015 Manila,Philippines [4]Department of Chemistry,College of Science,University of Santo Tomas,España Blvd.1015 Manila,Philippines [5]Graduate Institute of Natural Products,College of Pharmacy,Kaohsiung Medical University,Kaohsiung,Taiwan [6]Department of Mathematics and Natural Sciences,College of Arts and Sciences,Southern Luzon State University,Lucban 4328 Quezon,Philippines

出　　处：《Studies in Fungi》2022年第1期38-43,共6页真菌研究（英文）

基　　金：RRL Rondilla acknowledges the Accelerated Science and Technology Human Resource Development Program of the Department of Science and Technology-Science Education Institute(DOST-SEI)for the graduate scholarship grant.

摘　　要：Fungal endophytes offer structurally diverse and unique secondary metabolites with interesting biological activities.Several reports have shown the potential of fungal endophytes as sources ofα-glucosidase inhibitors to alleviate diabetes.In this study,the fungal endophyte Annulohypoxylon stygium(Xylariales,Ascomycota)was identified for the first time from the leaves of the endemic tropical plant,Pandanus simplex Merr.Crude extract was obtained by fermenting the fungal endophyte in Potato Dextrose Broth for 30 days at room temperature.The A.stygium crude extract exhibited good inhibition to theα-glucosidase enzyme with an IC_(50) of 31.88±2.86μg/mL.Purification of the crude extract afforded 8-methoxynaphthol with an IC_(50) value of 676.3±1.03μg/mL.The isolation of 8-methoxynaphthol from A.stygium is reported herein for the first time.This study highlights the ability of A.stygium to produce metabolites that may be useful as antidiabetic drugs.

关 键 词：TEMPERATURE xylon PANDA 

分 类 号：Q949.3[生物学—植物学]