创伤性脑损伤相关标记物的临床研究进展  

Clinical research progress of traumatic brain injury related markers

作　　者：李宁 莫业和[2] 刘达远 张华[2] 王康宁 LI Ning;MO Ye-he;LIU Da-yuan;ZAHNG Hua;WANG Kang-ning(Hainan Medical University,Haikou 571199,China;The Second Affiliated Hospital of Hainan Medical University,Haikou 570311,China)

机构地区：[1]海南医学院,海南海口571199 [2]海南医学院第二附属医院神经外科,海南海口570311

出　　处：《海南医学院学报》2023年第10期789-794,共6页Journal of Hainan Medical University

基　　金：海南省卫生计生行业科研项目(19A200017)。

摘　　要：创伤性脑损伤(TBI)是生物力学作用于脑组织导致的脑损伤,除原发性脑损伤外,局部脑组织损害、水肿和高颅压对周围脑组织形成的继发性脑损伤进一步加重病情。现代诊疗设备和医疗技术水平的提高,有助于对患者进行早期干预治疗措施,但由于病情特殊性及复杂的病理、生理反应,中枢神经系统常出现不可逆性损伤,致残率及病死率高。近年发现TBI发生过程中相关生物学标记与脑组织损伤、神经功能状态相关,并且在判断脑损伤严重程度及预后评估具有重要临床应用价值,被广泛研究。文章拟对TBI相关预后标志物的临床研究进展进行总结综述。Traumatic brain injury is a brain injury caused by biomechanics effects on brain tissue,In addition to primary brain injury,secondary brain injury caused by local brain injury,edema and high intracranial pressure on surrounding brain tissue further aggravates the disease.The improvement of modern medical equipment and medical technology can provide early intervention treatment for patients.However,due to the particularity of the disease and the complexity of pathological and physiological reactions,irreversible damage often occurs in the central nervous system,with high disability rate and mortality.In recent years,it has been found that the related biological markers in the process of TBI are related to brain tissue injury and neurological function,and have important clinical application value in judging the severity of brain injury and prognosis evaluation,which has been widely studied.This paper intends to summarize the clinical research progress of TBI-related prognostic markers.

关 键 词：创伤性脑损伤 相关标记物 临床研究 

分 类 号：R651.15[医药卫生—外科学]