三酰甘油葡萄糖指数与新诊断的冠状动脉粥样硬化性心脏病患者冠状动脉病变程度的相关性  

Correlation between triglyceride glucose index and severity of coronary artery disease in patients with newly diagnosed coronary heart disease

作　　者：高霞[1] 胡延晋[1] 姚志[1] 王广[1] Gao Xia;Hu Yanjin;Yao Zhi;Wang Guang(Department of Endocrinology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院内分泌科,北京100020

出　　处：《首都医科大学学报》2023年第3期381-386,共6页Journal of Capital Medical University

基　　金：国家自然科学基金面上项目(81972137)。

摘　　要：目的探讨三酰甘油葡萄糖(triglyceride glucose,TyG)指数在新诊断的冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)患者中与冠状动脉病变程度的相关性。方法纳入290例因胸痛于首都医科大学附属北京朝阳医院心内科住院的初次行冠状动脉造影的患者,测定患者的空腹血糖(fasting blood glucose,FBG)、糖化血红蛋白(glycosylated hemoglobin A1c,HbA1c)、三酰甘油(triglyceride,TG)及其他生物化学指标,计算TyG指数,根据冠状动脉造影结果分为非CHD组和CHD组,并按照冠状动脉病变程度进一步分为单支病变组、双支病变组、三支/左主干病变组。应用Logistic回归分析评估冠状动脉三支/左主干病变的影响因素。结果CHD组FBG、HbA1c高于非CHD组[FBG:(6.12±2.41)mmol/L vs(5.33±1.82)mmol/L,P<0.05;HbA1c:(6.79%±1.57%)vs(6.32%±1.08%),P<0.05]。三支/左主干病变组TyG指数(8.87±0.73)高于单支病变(8.63±0.62)及双支病变组(8.62±0.68),差异有统计学意义(P<0.05)。Logistic回归分析显示,年龄、TyG指数、TG、FBG、HbA1c是三支/左主干病变的独立影响因素,其中TyG指数每增加一个标准差,调整后的OR值(95%置信区间)为2.079(1.345,3.213)。结论TyG指数在冠状动脉三支/左主干病变组明显升高,并且是CHD患者冠状动脉三支/左主干病变的独立影响因素。Objective To explore the association between triglyceride glucose(TyG)index and degree of coronary artery lesion in patients with newly diagnosed coronary heart disease(CHD).Methods A total of 290 patients admitted in the department of cardiology,Beijing Chaoyang Hospital,Capital Medical University,for coronary angiography because of chest pain were included in the study.The level of fasting blood glucose(FBG),glycosylated hemoglobin A1c(HbA1c),triglyceride(TG)and other biochemical indicators were measured,and then the TyG index was calculated by using the value of FBG and TG.All patients were divided into non-CHD group and CHD group based on the coronary angiography results.The patients of CHD group were further stratified into groups based on the number of diseased vessels:single-vessel coronary artery disease(CAD),double-vessel CAD,and three-vessel/left main CAD according to the degree of stenosis.Multiple Logistic regression analysis was used to evaluate the association of three-vessel/left main CAD and other parameters in CHD patients.Results The patients of CHD group exhibited higher level of FBG and HbA1c compared with the subjects of non-CHD group[FBG:(6.12±2.41)mmol/L vs(5.33±1.82)mmol/L,P<0.05;HbA1c:6.79%±1.57%vs 6.32%±1.08%,P<0.05].TyG index in the three-vessels/left main disease group(8.87±0.73)was higher than that in the single(8.63±0.62)and double-vessel CAD groups(8.62±0.68)(P<0.05).Multiple Logistic regression analysis showed age,TyG index,TG,FBG,and HbA1c were independent risk factors for three-vessel/left main CAD,and the adjusted OR value(95%confidence interval)was 2.079(1.345,3.213)for each additional SD of TyG index.Conclusion TyG index was elevated in patients with three-vessel/left main CAD and it was significantly related to the risk of three-vessel/left main CAD.

关 键 词：冠状动脉粥样硬化性心脏病 三酰甘油葡萄糖指数 胰岛素抵抗 

分 类 号：R543[医药卫生—心血管疾病]