环孢素A治疗再生障碍性贫血对患者临床疗效、血常规指标及免疫功能的影响  

Effects of Cyclosporine A on Clinical Curative Effect,Blood Routine Index and Immune Function in Patients with Aplastic Anemia

作　　者：梁高飞[1] 刘观斌[2] 闫春平[1] LIANG Gaofei;LIU Guanbin;YAN Chunping(Department of Hematology,Binzhou Central Hospital,Binzhou,Shandong Province,251700 China;Department of Medical Laboratory,Binzhou Central Hospital,Binzhou,Shandong Province,251700 China)

机构地区：[1]滨州市中心医院血液内科,山东滨州251700 [2]滨州市中心医院医学检验科,山东滨州251700

出　　处：《中外医疗》2023年第8期103-106,111,共5页China & Foreign Medical Treatment

摘　　要：目的探讨再生障碍性贫血(aplastic anemia,AA)患者采用环孢素A进行治疗对临床疗效、血常规指标及免疫功能的影响。方法随机选取2019年1月—2022年1月滨州市中心医院收治的80例AA患者为研究对象,根据随机摸球法分成观察组(n=40)与对照组(n=40)。对照组采用常规药物治疗,观察组采用环孢素A治疗,对两组患者的临床疗效、血常规指标、免疫功能、生活质量及不良反应进行比较。结果观察组的治疗总有效率(97.50%)高于对照组(80.00%),差异有统计学意义(χ^(2)=4.507,P<0.05)。治疗后两组白细胞(WBC)、血小板(PLT)、血红蛋白(Hb)水平明显增高,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗后两组CD3^(+)、CD4^(+)水平明显增高,CD8^(+)水平明显降低;且观察组CD3^(+)、CD4^(+)水平高于对照组,观察组CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。治疗后两组世界卫生组织生存质量测定量表(WHOQOL-100)评分明显提高,观察组高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率(5.00%)低于对照组(22.50%),差异有统计学意义(χ^(2)=5.165,P<0.05)。结论环孢素A应用于AA患者治疗中,可提高临床疗效,提高血常规指标,改善免疫功能,提升生活质量,减少不良反应发生。Objective To investigate the effect of cyclosporine A on clinical efficacy,blood routine indexes and immune function in patients with aplastic anemia(AA).Methods A total of 80 AA patients admitted to Binzhou Central Hospital from January 2019 to January 2022 were randomly selected.They were divided into two groups according to the random touch method,namely the observation group(n=40)and the control group(n=40).The control group was treated with conventional drugs,and the observation group was treated with cyclosporine A.The clinical efficacy,blood routine indicators,immune function,quality of life and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(97.50%)was higher than that in the control group(80.00%),and the difference was statistically significant(χ^(2)=4.507,P<0.05).After treatment,the levels of white blood cells(WBC),platelets(PLT),and hemoglobin(Hb)in the two groups were significantly increased,and the observation group were higher than the control group,the difference was statistically significant(P<0.05).After treatment,the levels of CD3^(+)and CD4^(+)in the two groups were significantly increased,while the levels of CD8^(+)were significantly reduced;while the levels of CD3^(+)and CD4^(+)in the observation group were higher than those in the control group,while the levels of CD8^(+)in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of the World Health Organization Quality of Life Scale(WHOQOL-100)were significantly improved in both groups,with the observation group being higher than the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group(5.00%)was lower than that in the control group(22.50%),and the difference was statistically significant(χ^(2)=5.165,P<0.05).Conclusion The application of cyclosporine A in the treatment of patients with AA can imp

关 键 词：环孢素A 再生障碍性贫血 临床疗效 血常规指标 免疫功能 

分 类 号：R556[医药卫生—血液循环系统疾病]