纳米生物传感器探针材料:合成、组装及应用  

Probe Materials of Nanobiosensors:Synthesis,Assembly and Applications

作　　者：宋丽平 朱欣怡 黄又举 Li-ping Song;Xin-yi Zhu;You-ju Huang(College of Material,Chemistry and Chemical Engineering,Hangzhou Normal University,Hangzhou 311121)

机构地区：[1]杭州师范大学材料与化学化工学院,杭州311121

出　　处：《高分子学报》2023年第6期870-891,共22页Acta Polymerica Sinica

基　　金：国家自然科学基金(基金号52222316)资助项目。

摘　　要：生物传感器因选择性高、分析速度快、准确度高等特点,在生物医学、环境监测及食品安全等领域应用广泛.纳米探针材料是生物传感器中的核心部件,对检测信号的输出和放大,起到至关重要的作用.本文总结了近十年来本团队利用智能高分子精准调控纳米粒子合成的研究成果,发展了多种生长模式,量身定制出三十多种高效可医用探针材料;通过智能高分子修饰纳米探针表面,实现了不同维度(1D、2D和3D)的宏观可控自组装.最后,基于设计的探针材料及其组装结构,构建了一系列生物传感器,探索了其在食品安全检测和医疗诊断领域的应用.Biosensors are devices that are sensitive to biological substances and convert their changes into monitorable optical and electrical signals.Owing to their remarkable advantages of high selectivity,fast analysis speed and high accuracy,they are widely applied in biomedical,environmental monitoring and food safety.Nanoprobes,which play vital roles in the output and amplification of signals,are the core components of biosensors.The signals of nanoprobes are intrinsically related to their morphology,surface chemistry and assembled structure.In this feature article,we summarized our research on the following three aspects:(1)Use of intelligent polymers to precisely regulate the synthesis of nanoprobes through three growth modes,such as intelligent growth mode,chemically anchored seed-growth mode and micellar limited growth mode.Up to now,we have customized more than 30 kinds of efficient biomedical probe materials;(2)Developed the intelligent multifunctional surface engineering strategies on probe materials,and achieved 1D,2D and 3D self-assembly of nanoprobes by adjusting the dynamic and thermodynamic parameters;(3)Based on the designed probe materials,different types of biosensors such as SERS biosensor,fluorescent biosensor,electrochemical biosensor and colorimetric biosensor are constructed,and their applications in food safety detection and biomedical diagnosis are explored.

关 键 词：生物传感器 纳米探针 智能高分子 精准合成 可控自组装 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]