AGTR1(A1166C)基因多态性对高血压患者检验指标的影响  

Effects of AGTR1(A1166C)gene polymorphism on clinical laboratory indicators in patients with hypertension

作　　者：余汉忠 李磊[2] 董勃 孔倩倩 钮威 张凯 魏书瑶 方路 王丽 YU Hanzhong;LI Lei;Dong Bo;KONG Qianqian;NIU Wei;ZHANG Kai;WEI Shuyao;FANG Lu;WANG Li(Department of Clinical Laboratory,The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University,Xuzhou 221116,Jiangsu;Laboratory Department of Xuzhou Tumor Hospital,Xuzhou 221005,Jiangsu,China)

机构地区：[1]徐州医科大学附属徐州市立医院检验科,江苏徐州221116 [2]徐州市肿瘤医院检验科,江苏徐州221005

出　　处：《临床检验杂志》2023年第3期180-185,共6页Chinese Journal of Clinical Laboratory Science

基　　金：江苏省徐州市卫生健康委科技重点项目(XWKYHT20210531),彭城英才—医学青年后备人才项目(XWRCHT20220013)。

摘　　要：目的探讨血管紧张素Ⅱ1型受体[AGTR1(A1166C)]基因多态性对原发性高血压(EH)发病的影响及其与患者临床检验指标水平的关联。方法选取2022年1月至12月徐州市第一人民医院确诊的240例EH患者(EH组)作为研究对象,另选取同期体检健康者180例作为健康人对照组,分析高血压药物相关基因多态性的分布特征;根据AGTR1(A1166C)基因多态性检测结果,将EH患者分为AA组、AC/CC组,分析AGTR1(A1166C)基因多态性对2组EH患者肾素活性(PRA)、醛固酮(ALD)、脂蛋白a[Lp(a)]、血管紧张素2(AT2)、促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、总胆固醇(TC)、天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(T-Bil)、直接胆红素(D-Bil)、总胆汁酸(TBA)、尿素(Ure)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(apo A1)、载脂蛋白B(apo B)、载脂蛋白E(apo E)、碱性磷酸酶(ALP)、γ-谷氨酰基转移酶(GGT)、尿酸(UA)、血葡萄糖(Glu)、游离脂肪酸(NEFA)、小而密低密度脂蛋白胆固醇(sdLDL-C)、腺苷脱氨酶(ADA)、α-L-岩藻糖苷酶(AFU)、甘胆酸(CG)、肌酐(Cr)、胱抑素C(CysC)、果糖胺(FMN)、缺血修饰清蛋白(IMA)、高半胱氨酸(Hcy)等临床检验指标的影响。结果AGTR1(A1166C)基因型及基因位点频率分布在EH组和健康人对照组间的差异具有统计学意义(χ^(2)=24.815,P<0.05),具有AC/CC基因型的个体更易患EH;AC/CC组患者PRA、ALD、Lp(a)项目均显著高于AA组[PRA:Z=2.216,P=0.029;ALD:t=2.406,P=0.017;Lp(a):t=2.406,P=0.021];其余检验项目如AT2、TSH、FT3、FT4、TC、AST、ALT、T-Bil、D-Bil、TBA、Ure、TG、HDL-C、LDL-C、apo A1、apo B、apo E、ALP、GGT、UA、Glu、NEFA、sdLDL-C、ADA、AFU、CG、Cr、CysC、FMN、IMA、Hcy等在2组间的差异均无统计学意义(P>0.05)。结论AGTR1(A1166C)基因型和等位基因分布在EH患者和健康人群中存在显著差�Objective To investigate the effects of angiotensinⅡtype 1 receptor gene AGTR1(A1166C)polymorphism on the pathogenesis of essential hypertension(EH)and its association with the relevant clinical laboratory indicators.Methods A total of 240 patients with essential hypertension(EH group)confirmed by Xuzhou First People′s Hospital from January to December 2022 were selected as the research subjects,and 180 healthy individuals who underwent physical examination in our hospital during the same period were selected as the control group.The distribution characteristics of gene polymorphisms related to anti-hypertension drug were analyzed.Based on the test results of AGTR1(A1166C)gene polymorphism,the enrolled hypertensive patients were divided into AA group and AC/CC group,and the impacts of AGTR1(A1166C)gene polymorphism on 35 clinical laboratory indicators were analyzed in the two groups,including renin activity(PRA),aldosterone(ALD),lipoprotein a[Lp(a)],angiotensin 2(AT2),thyroid hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4),total cholesterol(TC),glutamic transaminase(AST),glutamate transaminase(ALT),total bilirubin(T-Bil),direct bilirubin(D-Bil),total bile acid(TBA),urea(Ure),triglyceride(TG),high-density lipoprotein(HDL-C),low-density lipoprotein(LDL-C),apolipoprotein A1(apo A1),apolipoprotein B(apo B),apolipoprotein E(apo E),alkaline phosphatase(ALP),γ-glutamate transferase(GGT),uric acid(UA),blood glucose(Glu),free fatty acids(NEFA),small and dense low-density lipoprotein cholesterol(sdLDL-C),adenosine deaminase(ADA),α-L-fucosidase(AFU),glycocholic acid(CG),creatinine(Cr),cystatin C(CysC),fructosamine(FMN),ischemia modified albumin(IMA)and homocysteine(Hcy).Results There were statistically significant differences between the two groups in genotype and genotype frequency distribution of AGTR1(A1166C)(χ^(2)=24.815,P<0.05).The individuals with AC/CC genotype were more likely to suffer from essential hypertension.In the AC/CC group of EH patients,renin activity(PRA),levels of aldosterone(ALD)and

关 键 词：血管紧张素Ⅱ1型受体 基因多态性 原发性高血压 检验指标 

分 类 号：R446[医药卫生—诊断学] R544.1[医药卫生—临床医学]