泛素连接酶与帕金森病发病机制中线粒体自噬和内质网应激的研究进展  

Roles of ubiquitin ligases in mitophagy and endoplasmic reticulum stress in the pathogenesis of Parkinson′s disease

作　　者：梁宇 任铭心 王凯丽 仲光尚 叶明[3] 刘长青 LIANG Yu;REN Mingxin;WANG Kaili;ZHONG Guangshang;YE Ming;LIU Changqing(School of Clinical Medicine,Bengbu Medical College,Bengbu 233000,China;School of Life Sciences;Department of Neurology,the First Affiliated Hospital of Bengbu Medical College)

机构地区：[1]蚌埠医学院临床医学院,安徽蚌埠233000 [2]蚌埠医学院生命科学学院 [3]蚌埠医学院第一附属医院

出　　处：《沈阳医学院学报》2023年第3期295-300,共6页Journal of Shenyang Medical College

基　　金：国家自然科学基金项目(No.81771381);安徽省重点研究与开发计划项目(No.2022e07020030);蚌埠医学院重大科技项目孵育计划(No.2021byfy002);国家级大学生创新创业训练项目资助(No.202110367037)。

摘　　要：帕金森病(Parkinson's disease,PD)是一种常见的多发于中老年的神经退行性疾病,随着我国人口老龄化日益严重,PD的发病人数逐渐增加。泛素蛋白酶体系统可以通过调控线粒体自噬和内质网应激两大过程影响PD的发生发展。泛素连接酶是泛素蛋白酶体系统的重要组成部分,本文重点就泛素连接酶通过线粒体自噬和内质网应激途径与PD发生发展的相关性进行深入的探讨,详细阐述其在泛素依赖型线粒体自噬和内质网应激中的区别与联系,为开展泛素连接酶相关的PD发病机制的研究与临床治疗提供借鉴。Parkinson's disease(PD)is a common neurodegenerative disease that mostly occurs in middle-aged and elderly people.With the aging of our population becoming increasingly serious,the incidence of PD is rising gradually.Ubiquitin proteasome system can affect the occurrence and development of PD by regulating mitochondrial autophagy and endoplasmic reticulum stress.Ubiquitin ligases are important components of the ubiquitin proteasome system.This paper summarizes the correlation between ubiquitin ligase and the occurrence and development of PD through mitochondrial autophagy and endoplasmic reticulum stress,so as to provide valuable ideas for the treatment research of PD related to ubiquitin ligase.

关 键 词：泛素连接酶 帕金森病 线粒体自噬 内质网应激 

分 类 号：R473[医药卫生—护理学]