载美洲大蠊有效部位CII-3 PDLLA微球的制备及制剂学评价  

Preparation and Evaluation of PDLLA Microspheres Loaded with the Active Site CII-3 of Periplaneta Americana

作　　者：袁近津 王亚伦 朱站站 王天龙 王绍仙 李婧炜 Yuan Jinjin;Wang Yalun;Zhu Zhanzhan;Wang Tianlong;Wang Shaoxian;Li Jingwei(College of Pharmacy,Dali University,Dali 671000,China)

机构地区：[1]大理大学药学院,云南大理671000

出　　处：《广东化工》2023年第9期77-81,76,共6页Guangdong Chemical Industry

摘　　要：采用乳化溶剂挥发法,以PEG修饰的PDLLA为原材料,制备载美洲大蠊有效部位CII-3 PDLLA微球。通过单因素试验以及正交试验优化制备工艺,并对微球进行表征,通过对微球的体外释放规律和稳定性进行初步研究。结果显示,所制备的微球载药量为1.22%,包封率为43.03%,平均粒径为97μm。微球形态圆整,表面存在密集小孔,具有良好的释药特性。初步稳定性考察表明,微球能够在一定程度上保护美洲大蠊有效部位CII-3不受到胃酸以及各种酶的影响从而失活,可为CII-3的进一步开发应用提供理论依据。PEG-modified PDLLA was used as the raw material for the preparation of CII-3 PDLLA microspheres containing the active part of Periplaneta Americana by emulsification solvent volatilization method.The preparation process was optimized by single-factor test as well as orthogonal test,and the microspheres were characterized by a preliminary study on the in vitro release pattern and stability of the microspheres.The results showed that the prepared microspheres had a drug loading of 1.22%,an encapsulation rate of 43.03%,and an average particle size of 97μm.The microspheres had a rounded morphology and dense small pores on the surface,which had good drug release characteristics.The preliminary stability study showed that the microspheres could protect the active part of Periplaneta Americana CII-3 from the influence of gastric acid and various enzymes,which could provide a theoretical basis for the further development and application of CII-3.

关 键 词：美洲大蠊 微球 单因素试验 正交试验 体外释放 

分 类 号：R283.6[医药卫生—中药学]