大鼠肝微粒体体外代谢多溴联苯醚(PBDEs)类污染物的研究  

In vitro Metabolism of Polybrominated Diphenyl Ethers(PBDEs)by Rat Liver Microsomes

作　　者：罗远来 刘业贵 王晶 邓景衡 Luo Yuanlai;Liu Yegui;Wang Jing;Deng Jingheng(College of Life Sciences,Hengyang Normal University,Hengyang 421008,China)

机构地区：[1]衡阳师范学院生命科学学院,湖南衡阳421008

出　　处：《广东化工》2023年第9期82-84,117,共4页Guangdong Chemical Industry

基　　金：湖南省教育厅科学研究项目优秀青年基金(20B084);“南岳山区生物资源保护与利用”湖南省重点实验室开放基金项目(NY20K06);衡阳师范学院大学生创新创业训练项目(cxcy2021031)。

摘　　要：多溴联苯醚(PBDEs)是一类在工业上被广泛使用的阻燃剂,具有环境持久性、生物可富集性、生物毒害性等持久性有机污染物(POPs)的特点。PBDEs具有众多不同的单体,其在不同生物体内表现出不同的单体组成特征。为了调查主要PBDEs在大鼠(哺乳动物模式生物)中的差异性代谢模式及探究原因,本文研究了大鼠肝微粒体对BDE-47和BDE-99的代谢产物和途径,对其差异性代谢特点进行比较,并就参与反应的酶种类和活性对该现象的原因进行了初步讨论。Polybrominated diphenyl ethers(PBDEs)are a class of flame retardants widely used in industry.They have the characteristics of persistent organic pollutants(POPs)such as environmental persistence,bioaccumulation,and biological toxicity.PBDEs have many different monomers,which show different monomer composition characteristics in different organisms.In order to investigate the differential metabolic patterns of major PBDEs in rats(mammalian model organisms)and explore the reasons,this paper studied the metabolites and pathways of rat liver microsomes to BDE-47 and BDE-99,compared their differential metabolic characteristics,and preliminarily discussed the reasons for this phenomenon from the perspective of the types and activities of enzymes involved in the reaction.

关 键 词：多溴联苯醚 大鼠肝微粒体 体外代谢 持久性有机污染物 CYP酶 

分 类 号：X592[环境科学与工程—环境工程]