苯二氮䓬类镇静催眠药的分析检测及代谢研究进展  

Research Progress of Analysis,Determination and Metabolism Study of the Benzodiazepine Sedative Hypnotics

作　　者：刘思琦 徐静宜 周姝含 方鹏凯 宋晓婷 杨光明[1] 吴亮[1] Liu Siqi;Xu Jingyi;Zhou Shuhan;Fang Pengkai;Song Xiaoting;Yang Guangming;Wu Liang(School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学药学院,江苏南京210023

出　　处：《广东化工》2023年第9期199-202,共4页Guangdong Chemical Industry

基　　金：2020年国家级大学生创新创业训练计划项目(202010315031);2020年江苏省大学生创新创业训练计划项目(202010315018Z);江苏省食品药品与环境犯罪检验技术工程实验室开放课题(SYHKF01)。

摘　　要：苯二氮䓬类药物具有镇静催眠、抗焦虑、抗惊厥、肌肉松弛等药理作用,临床应用广泛,安全性较高。然而,该类药物的滥用会导致成瘾性,并带来严重的社会危害。因此,需要结合现代分析技术,对该类药物的使用进行严格的管控和追踪。本文主要综述了近年来国内外苯二氮䓬类镇静催眠药在分析检测和体内外代谢等方面的研究进展,以期为该类药物的监测和控制提供依据。Benzodiazepines are a class of sedative-hypnotics with high safety and wide clinical application,which have the effect of sedative-hypnotic,anxiolytic,anticonvulsant,and muscle relaxant.However,abuse of benzodiazepines may lead to addiction and cause serious social harm.Therefore,modern analytical technology was needed,to perform strict management and trailing during the use of benzodiazepines.This paper reviews the research progress of benzodiazepine sedative-hypnotics at home and abroad in recent years,mainly in the field of their analysis and determination,and metabolism study both in vivo and in vitro.The review is aiming at providing scientific evidence for the monitoring and control of benzodiazepines.

关 键 词：苯二氮䓬类 镇静催眠药 分析检测 代谢研究 研究进展 

分 类 号：R971.3[医药卫生—药品]