镉基同手性双配体金属有机框架高效液相色谱柱拆分手性物质安息香  

Chiral Separation of Benzoin by Cd Coordinated and Double Ligand Homochiral Metal Organic Framework HPLC Column Material

作　　者：潘玉 张家昌 沙涛[1] 沈静茹[1] Pan Yu;Zhang Jiachang;Sha Tao;Shen Jingru(Key Laboratory of Analytical Chemistry of State Ethnic Affairs Commission,College of Chemistry and Materials Science,South-Central MinZu University,Wuhan 430074,China)

机构地区：[1]中南民族大学化学与材料科学学院分析化学国家民委重点实验室,湖北武汉430074

出　　处：《广东化工》2023年第9期206-210,共5页Guangdong Chemical Industry

基　　金：中央高校基本科研业务费专项资金项目(CZY20036)。

摘　　要：论文采用一锅法合成了以镉为中心离子,与L-苏氨酸,4,4-联吡啶为双配体并使之原位生长在高效液相色谱((HPLC,High performance liquid chromatography))硅珠(SiO_(2))表面的同手性金属有机框架复合材料Cd-HMOF@SiO_(2),所得复合材料Cd-HMOF@SiO_(2)通过扫描电镜、傅里叶红外光谱和圆二色光谱进行表征,证明了Cd-HMOF@SiO_(2)的成功合成。将Cd-HMOF@SiO_(2)填充成高效液相色谱手性固定相(CSP,Chiral stationary phase),对手性药物安息香进行了拆分条件优化,分别进行了流动相比例、流动相流速、重现性、线性范围和线性相关性探究,安息香两对映体在最佳分离条件下分离度R为3.84,最大分离度R可达4.90。In this paper,the homochiral metal organic frame composites with cadmium as the central ion and L-threonine,4,4-neneneba bipyridine as the double ligand were synthesized by one pot method and in-situgrown on the surface of high performance liquid chromatography(HPLC)silica beads(SiO_(2)).It was resulting composite materials Cd-HMOF@SiO_(2).The successful synthesis of the composite material was demonstrated through characterization using scanning electron microscopy,Fourier transform infrared spectroscopy,and circular dichroism spectroscopy.Afterwards,the composite material was used to fill the chiral stationary phase(CSP)of HPLC,and the separation conditions of chiral drug benzoin were optimized.The mobile phase ratio,mobile phase flow rate,reproducibility,linearity range and linear correlations were investigated,respectively.The separation degree R of benzoin by the optimal separation condition was 3.84.The biggest separation degree R of benzoin was 4.90.

关 键 词：同手性双配体金属有机框架 高效液相色谱柱材料 对映体手性分离 安息香 

分 类 号：O641.4[理学—物理化学] O652.63[理学—化学]