阿利吉仑的抗高血压及肾脏保护作用研究进展  

Recent Progress on Aliskiren in the Antihypertension and Kidney Protection

作　　者：王欣 张雨蝶 谭雄 余双 祁亚澜 贺茂芳 Wang Xin;Zhang Yudie;Tan Xiong;Yu Shuang;Qi Yalan;He Maofang(College of Pharmacy,Institute of Medicine,Xi’an Medical University,Xi’an 710021,China;School of Pharmacy,Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]西安医学院药学院,药物研究所,陕西西安710021 [2]成都医学院药学院,四川成都610500

出　　处：《山东化工》2023年第6期71-73,共3页Shandong Chemical Industry

基　　金：陕西省科技厅重点研发计划(2021ZDLSF03-05);陕西省教育厅自然科学基础计划(21JK0894);教育部产学合作协同育人项目(202101021043);西安医学院大学生创新训练项目(121520030);西安医学院校级科技创新团队(2021TD03、2021TD07);西安医学院校级重点药学学科(西医发[2019]96号)资助。

摘　　要：目的:总结近年来阿利吉仑在抗高血压及肾脏保护方面的研究进展。方法:查阅国内外文献,总结归纳阿利吉仑单用和联合用药的降压效果、肾脏保护作用及其安全性。结果:阿利吉仑单药治疗的降压效果良好且呈剂量依赖性,与血管紧张素受体抑制剂、钙离子通道阻滞剂、嗪类利尿剂等联合治疗也有较好的协同疗效和耐受性。此外,阿利吉仑还有降低蛋白尿,保护肾脏、心血管等功效。结论:阿利吉仑是一种理想的抗高血压药物,为高血压的临床治疗提供了新选择。Objective:To summarize the research progress of aliskiren in antihypertensive and kidney protection in recent years.Methods:The domestic and foreign literatures were reviewed,and then the antihypertensive effect,renal protection effect and safety of aliskiren monotherapy or combination therapy with other antihypertensive drugs were summarized.Results:The antihypertensive effect of aliskiren monotherapy was good and dose-dependent,and the combination with angiotensin receptor inhibitors,calcium channel blockers,and azine diuretics also had good synergistic efficacy and tolerance.In addition,aliskiren also reduces proteinuria,protects the kidneys and cardiovascular.Conclusion:Aliskiren is an ideal antihypertensive drug,which provides a new choice for the clinical treatment of hypertension.

关 键 词：肾素抑制剂 阿利吉仑 抗高血压 肾脏保护 

分 类 号：TQ60[化学工程] R972.4[医药卫生—药品]