改善心力衰竭能量代谢的潜在药物研究进展  

Advances in potential drugs for improvement of energy metabolism in heart failure

作　　者：史小飞 陈弋 陈枫 景凯 高越 刘霞 SHI Xiaofei;CHEN Yi;CHEN Feng;JING Kai;GAO Yue;LIU Xia(School of Pharmacy,Naval Medical University,Shanghai 200433,China;Clinical Research Center of the First Affiliated Hospital,Naval Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学药学系,上海200433 [2]海军军医大学第一附属医院临床研究中心,上海200433

出　　处：《药学实践与服务》2023年第5期284-290,共7页Journal of Pharmaceutical Practice and Service

摘　　要：心力衰竭(HF)是一个全球性的公共卫生问题,发病率和死亡率都很高。研究表明,HF是由严重的能量代谢紊乱引起的,导致心脏能量供应不足。这种能量缺乏会导致心脏泵血功能障碍和全身其他器官能量代谢的衰竭。针对HF的疗法主要通过降低心率和心脏前负荷和后负荷、对症治疗或延缓疾病的发展来发挥作用。然而,针对心脏能量代谢的药物却尚未研发出来。本文概述健康心脏中能量代谢的主要特征、HF期间的代谢变化,并讨论通过能量代谢来改善心脏功能的药物,为治疗HF药物的研发和应用提供新的研究方向。Heart failure(HF)is a global public health problem with high morbidity and mortality.Numerous studies have shown that HF is caused by severe disturbance of energy metabolism,resulting in insufficient cardiac energy supply.This lack of energy could lead to a failure of the heart to pump blood and a failure of energy metabolism in other organs throughout the body.Currently,therapeutics of HF work by reducing heart rate and cardiac preload and afterload,symptomatic treatment,or delaying the progression of the disease.However,drugs targeting heart energy metabolism have not been developed.the main characteristics of cardiac energy metabolism,metabolic changes during HF were summarized and drugs that improve cardiac function through energy metabolism were discussed,which could provide a new research direction for the development and application of drugs in treatment of heart failure.

关 键 词：心力衰竭 能量代谢 抗心力衰竭药物 

分 类 号：R972[医药卫生—药品]