Cross-sectional associations between cortical thiclmess and physical activity in older adults with spontaneous memory complaints:The MAPT Study  

作　　者：Jérémy Raffin Yves Rolland Clara Fischer Jean-Francois Mangin Audrey Gabelle Bruno Vellas Philipe de Souto Barreto the MAPT/DSA Group 

机构地区：[1]Gérontopôle de Toulouse,Institut du Vieillissement,Centre Hospitalo-Universitaire de Toulouse,Toulouse 31000,France [2]UniversitéPaul-Sabatier/Institut National de la Santéet de la Recherche Médicale UnitéMixte de Recherche 1027,Facultéde médecine,University of Toulouse Ⅲ,Toulouse 31000,France [3]Centre pour l'Acquisition et le Traitement des Images Multicenter Neuroimaging Platform,Neurospin,UniversitéParis-Saclay,Gif sur Yvette 91191,France [4]Memory Resources and Research Center,Montpellier University Hospital,Montpellier 34295,France [5]Institut National de la Santéet de la Recherche Médicale Unité1061 i-site Montpellier Universitéd'Excellence,University of Montpellier,Montpellier 34090,France [6]不详

出　　处：《Journal of Sport and Health Science》2023年第3期324-332,共9页运动与健康科学（英文）

基　　金：supported by grants from the Region Occitanie/Pyrenees-Mediterranee(No.1901175);the European Regional Development Fund(ERDF)(project No.MP0022856);received funds from Alzheimer Prevention in Occitania and Catalonia(APOC Chair of Excellence-Inspire Program);supported by grants from the Gerontopole of Toulouse,French Ministry of Health(PHRC 2008 and PHRC 2009);Pierre Fabre Research Institute(manufacturer of the omega-3 supplement);Exonhit Therapeutics SA;Avid Radiopharmaceuticals Inc;supported by the University Hospital Center of Toulouse;supported by the Association Monegasque pour la Recherche sur la maladie d’Alzheimer(AMPA);the INSERM-University of ToulouseⅢUMR 1027 Unit。

摘　　要：Background:Age-related changes in brain structure may constitute the starting point for cerebral function alteration.Physical activity(PA)demonstrated favorable associations with total brain volume,but its relationship with cortical thickness(CT)remains unclear.We investigated the cross-sectional associations between PA level and CT in community-dwelling people aged 70 years and older.Methods:A total of 403 older adults aged 74.8±4.0 years(mean±SD)who underwent a baseline magnetic resonance imaging examination and who had data on PA and confounders were included.PA was assessed with a questionnaire.Participants were categorized according to PA levels.Multiple linear regressions were used to compare the brain CT(mm)of the inactive group(no PA at all)with 6 active groups(growing PA levels)in 34 regions of interest.Results:Compared with inactive persons,people who achieved PA at a level of 1500-1999 metabolic equivalent task-min/week(i.e.,about6-7 h of brisk walking for exercise) and those who achieved it at 2000-2999 metabolic equivalent task-min/week(i.e.,8-11 h of brisk walking for exercise)had higher CT in the fusiform gyrus and the temporal pole.Additionally,dose-response associations between PA and CT were found in the fusiform gyrus(B=0.011,SE=0.004,adj.p=0.035),the temporal pole(B=0.026,SE=0.009,adj.p=0.048),and the caudal middle frontal gyrus,the entorhinal,medial orbitofrontal,lateral occipital,and insular cortices.Conclusion:This study demonstrates a positive association between PA level and CT in temporal areas such as the fusiform gyrus,a brain region often associated to Alzheimer’s disease in people aged 70 years and older.Future investigations focusing on PA type may help to fulfil remaining knowledge gaps in this field.

关 键 词：Alzheimer's disease Brain aging Cortical thickness Physical activity 

分 类 号：G804.2[文化科学—运动人体科学] R749.1[文化科学—体育学]