吴茱萸碱制剂的研究进展  

Research Progress on Pharmaceutical Preparation of Evodiamine

作　　者：黄秋妹[1] 石茗[1] 王珍 倪明龙[1] 阙慧卿 Huang Qiumei;Shi Ming;Wang Zhen;Ni Minglong;Que Huiqin(Guangdong Food and Drug Vocational College,Guangzhou 510520;Fujian Academy of Medical Sciences,Fujian Provincial Key Laboratory of Medical Test,Fuzhou 350122,China)

机构地区：[1]广东食品药品职业学院,广东广州510520 [2]福建省医学科学研究院药物所,福建福州350122

出　　处：《广东化工》2023年第10期66-68,79,共4页Guangdong Chemical Industry

基　　金：广东省中医药局项目(20201244);广东省医学科研基金项目(A2022404);广东食品药品职业学院自然科学研究项目(2019ZR05)。

摘　　要：吴茱萸碱是具有抗肿瘤、降血脂、降血糖、治疗痛风等多种活性的色胺吲哚类生物碱,因其在水中的溶性差及生物利用度低等影响其应用。许多学者开发新制剂以提高吴茱萸碱的溶解度和生物利用度。本文综述了国内外吴茱萸碱制剂的相关研究,并阐述其在动物实验中的应用,为其后续制剂开发及临床应用提供必要的思路和参考。Evodiamine(EVO)is a tryptamine indole alkaloids compound with various biological activities such as anti-cancer,treat gout,reduce blood lipid and blood sugar.It has a wide range of pharmacological activities.However,ower water solubility and bioavailability limit its clinical application.In order to improve its solubility and bioavailability,many researchers have studied new dosage forms of evodiamine.Research progress on pharmaceutical preparation of evodiamine and their applications in animal experiments are reviewed in this article,in order to provide necessary ideas and references for the future research.

关 键 词：吴茱萸碱 制剂 生物利用度 研究进展 

分 类 号：R283.6[医药卫生—中药学]