二氢苯并呋喃衍生物的合成及核磁共振研究  

The Synthesis and NMR Study of Dihydrobenzofuran-carboxamide Derivatives

作　　者：何鹏 龚慧雯 李昀珈 欧阳欣瑶 谢淑芳 刘宇龙 钟尉华 周中高 HE Peng;GONG Huiwen;LI Yunjia;OUYANG Xinyao;XIE Shufang;LIU Yulong;ZHONG Weihua;ZHOU Zhonggao(School of Chemistry and Chemical Engineering,Gannan Normal University,Ganzhou 341000,China;Key Laboratory of Jiangxi University for Functional Material Chemistry,Gannan Normal University,Ganzhou 341000,China)

机构地区：[1]赣南师范大学化学化工学院,江西赣州341000 [2]江西省高校功能材料化学重点实验室,江西赣州341000

出　　处：《赣南师范大学学报》2023年第3期31-36,共6页Journal of Gannan Normal University

基　　金：国家自然科学基金资助项目(22261002);研究生创新基金项目(YCX21A025);大学生创新创业训练计划项目(CX210052);江西省教育厅研究项目(GJJ201427,SZUGSHX2022-1043)

摘　　要：采用直接缩合法先制备苯并呋喃衍生物普卡必利,进一步合成普卡必利琥珀酸盐,并获得微量药物杂质普卡必利-N-氧化物.结合液体核磁共振一维和二维谱(^(1)H、^(13)C、DEPT135、DEPT45、DEPT90、^(1)H-^(1)H COSY、^(1)H-^(13)C HSQC、^(1)H-^(13)C HMBC)对普卡必利、普卡必利琥珀酸盐和普卡必利-N-氧化物的氢和碳信号进行系统的核磁共振对比研究.The dihydrobenzofuran-carboxamide derivative Prucalopride was first prepared by direct condensation.Prucalopride was used as starting material for the synthesis of prucalopride succinate.In this paper,^(1)H,^(13)C,DEPT,^(1)H-^(1)H COSY,^(1)H-^(13)C HSQC,and^(1)H-^(13)C HMBC of Prucalopride,Prucalopride succinate and Prucalopride-n-oxide were reported.The^(1)H and^(13)C NMR chemical shift of these compounds were completely assigned.

关 键 词：液体磁共振 二氢苯并呋喃衍生物 普卡必利 琥珀酸普卡必利 普卡必利-N-氧化物 

分 类 号：O482.53[理学—固体物理]