五运六气膏方对慢性阻塞性肺疾病西北寒燥证患者肺功能及炎症状态的影响  

Effects of Wuyun Liuqi Ointment on Pulmonary Function and Inflammatory State in Patients with Chronic Obstructive Pulmonary Disease and Northwest Cold and Dryness Syndrome

作　　者：李英[1] 刘艳丽 范佳 赵洪霄[1] LI Ying;LIU Yanli;FAN Jia;ZHAO Hongxiao(Dept.of Traditional Chinese Medicine,People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院中医科,乌鲁木齐830001

出　　处：《中国医院用药评价与分析》2023年第5期552-555,560,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：新疆维吾尔自治区卫生健康青年医学科技人才专项科研项目(No.WJWY-202126)。

摘　　要：目的:观察五运六气膏方对慢性阻塞性肺疾病(COPD)西北寒燥证患者的治疗效果。方法:选取2021年该院收治的COPD西北寒燥证患者100例,采用计算机随机数字分组法分为对照组50例和治疗组50例。对照组患者给予沙美特罗替卡松粉吸入剂治疗,治疗组患者在对照组基础上口服五运六气膏方治疗。持续治疗8周后,评估两组患者的临床疗效和中医证候改善程度,观察两组患者治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))和FEV_(1)占预计值百分比(FEV_(1)%)]、呼吸困难评分(mMRC)及患者自我评估测试(CAT)评分的变化,检测患者血清转化生长因子β1(TGF-β1)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和白细胞介素10(IL-10)等炎症因子水平的变化。结果:治疗组患者临床总有效率为88.0%(44/50),高于对照组的72.0%(36/50),差异有统计学意义(P<0.05)。治疗8周后,两组患者中医证候评分,mMRC、CAT评分,血清TNF-α、TGF-β1和IL-6水平较治疗前明显降低(P<0.05),IL-10和肺功能指标(FVC、FEV_(1)和FEV_(1)%)水平明显升高(P<0.05);治疗组患者中医证候评分,mMRC、CAT评分,血清TNF-α、TGF-β1和IL-6水平明显低于对照组(P<0.05),血清IL-10和肺功能指标(FVC、FEV_(1)和FEV_(1)%)水平明显高于对照组(P<0.05),上述差异均有统计学意义。结论:联合应用五运六气膏方可有效减轻COPD西北寒燥证患者的临床症状,降低血清炎症因子水平,对改善患者肺功能、提升患者生活质量具有积极意义,其疗效优于沙美特罗替卡松粉吸入剂单独治疗。OBJECTIVE:To observe the therapeutic effects of Wuyun Liuqi ointment on pulmonary function and inflammatory state in patients with chronic obstructive pulmonary disease(COPD)and northwest cold and dryness syndrome.METHODS:Totally 100 patients with COPD and northwest cold and dryness syndrome admitted into the hospital in 2021 were extracted to be divided into the control group and treatment group by computer random number grouping method,with 50 cases in each group.The control group was treated with salmeterol xinafoate and fluticasone propionate powder for inhalation,while the treatment group were treated with Wuyun Liuqi ointment on the basis of the control group.received Wuyun Liuqi ointment.The clinical efficacy and improvement of traditional Chinese medicine syndrome were evaluated in two groups.Changes of pulmonary function indicators[forced vital capacity(FVC),forced expiratory volume at one second(FEV_(1))and FEV_(1)%],modified medical research council dyspnea scale(mMRC)and patient self-assessment test(CAT)score of two groups were observed.The serum levels of transforming growth factor-β1(TGF-β1),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-10(IL-10)were detected.RESULTS:The total effective rate of the treatment group was 88.0%(44/50),higher than 72.0%(36/50)of the control group,the difference was statistically significant(P<0.05).After 8 weeks of treatment,the traditional Chinese medicine syndrome score,mMRC,CAT,serum TNF-α,TGF-β1 and IL-6 levels were significantly lower than those before treatment in two groups(P<0.05),and the IL-10 level and pulmonary function indicators(FVC,FEV_(1) and FEV_(1)%)were significantly higher than those before treatment(P<0.05);the traditional Chinese medicine syndrome score,mMRC,CAT,serum TNF-α,TGF-β1 and IL-6 levels in the treatment group were significantly lower than those in the control group(P<0.05),and the serum IL-10 level and pulmonary function indicators(FVC,FEV_(1) and FEV_(1)%)were significantly higher than those in the control group

关 键 词：慢性阻塞性肺疾病 西北寒燥证 五运六气 中药膏方 

分 类 号：R932[医药卫生—生药学]