5%米诺地尔联合非那雄胺治疗雄激素性脱发的疗效和安全性的Meta分析  

Meta-Analysis of Efficacy and Safety of 5%Minoxidil Combined with Finasteride in the Treatment of Androgenic Alopecia

作　　者：刘海燕[1] LIU Haiyan(Dept.of Alopecia,Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine,Changsha 410006,China)

机构地区：[1]湖南省中医药研究院附属医院脱发科,长沙410006

出　　处：《中国医院用药评价与分析》2023年第5期601-605,609,共6页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:评价5%米诺地尔联合非那雄胺治疗雄激素性脱发(AGA)的疗效和安全性,为该药的临床应用提供循证参考。方法:检索PubMed、the Cochrane Library、中国知网、维普数据库、中国生物医学文献数据库和万方数据库,纳入2022年6月1日前发表的有关5%米诺地尔联合非那雄胺治疗AGA的随机对照试验(RCT)。依次通过浏览标题、摘要和全文筛选文献,应用RevMan 5.4统计软件进行Meta分析。结果:经过筛选后,纳入7项RCT研究。Meta分析结果示,治疗3、6和12个月后,联合治疗组AGA患者的疗效优于5%米诺地尔组或非那雄胺组,差异均有统计学意义(P均<0.01);外用5%米诺地尔的不良反应发生率高于口服非那雄胺,差异有统计学意义(P<0.01)。结论:对于AGA患者,外用5%米诺地尔联合口服非那雄胺的效果最佳。但用药期间会有局部瘙痒、皮屑增加或皮炎发生,应注意皮肤及其附件不良反应的发生;或可发生性功能障碍等不良反应,应给予关注;用药期间应及时关注患者的肝功能。and full text in turn,and Meta-analysis was performed by using RevMan 5.4 statistical software.RESULTS:After screening,7 RCT were included.Results of Meta-analysis showed that after 3,6 and 12 months of treatment,the efficacy of AGA in the combined treatment group was better than that in the 5%minoxidil group or finasteride group,the differences were statistically significant(P<0.01).The incidence of adverse drug reactions of topical 5%minoxidil was significantly higher than that of oral finasteride,the difference was statistically significant(P<0.01).CONCLUSIONS:For patients with AGA,topical 5%minoxidil combined with oral finasteride is the most effective.However,local itching,increased dandruff or dermatitis may occur during medication,and attention should be paid to the occurrence of adverse reactions on the skin and its accessories.Adverse drug reactions such as sexual dysfunction may occur and should be given attention,patient’s liver function should be promptly monitored during drug medication.

关 键 词：米诺地尔 非那雄胺 雄激素性脱发 疗效 安全性 META分析 

分 类 号：R986[医药卫生—药品]