血清sST2、RF、CCP抗体水平与类风湿性关节炎疗效指标的相关性分析  

Correlation Analysis of Serum sST2,RF and CCP Antibody Levels with the Efficacy of Rheumatoid Arthritis

作　　者：王璐璐 尤鑫 李萌[1] WANG Lu-lu;YOU Xin;LI Meng(The Fifth Clinical Medical Collegeof Henan University of Traditional Chinese Medicine,Zhengzhou People's Hospital,HenanZhegnzhou 450000)

机构地区：[1]河南中医药大学第五临床医学院,郑州人民医院,河南郑州450000

出　　处：《深圳中西医结合杂志》2023年第5期13-15,共3页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:观察血清可溶性基质裂解素2(sST2)、类风湿因子(RF)、抗环瓜氨酸肽(CCP)抗体水平与类风湿性关节炎(RA)疗效指标的相关性。方法:选取郑州人民医院2020年1月至2022年1月收治的72例RA患者,规范化治疗6个疗程后,观察患者的临床疗效,并比较治疗前后患者血清sST2、RF、CCP抗体水平及常规疗效指标C反应蛋白(CRP)、红细胞沉降率(ESR)、疾病活动度评分(DAS28)〕,分析患者血清sST2、RF、CCP抗体与水平临床疗效、各项常规疗效指标的相关性。结果:72例患者治疗后的总有效率为91.67%;治疗后患者血清sST2、RF、CCP抗体、DAS28、ESR、CRP水平均低于治疗前,差异均具有统计学意义(P<0.05);相关性分析结果显示,患者血清sST2、RF、CCP抗体水平与临床疗效均呈正相关,与常规疗效指标DAS28、ESR、CRP也均呈正相关。结论:血清sST2、RF、CCP抗体与RA疗效间具有明确的相关性,能够为RA疗效的评估提供参考。Objective To observe the correlation between the serum levels of soluble suppression of tumorigenicity-2(sST2),rheumatoid factor(RF),anti cyclic citrullinated peptide(CCP)antibodies and the therapeutic indexes of rheumatoid arthritis(RA).Methods 72 RA patients admitted to Zhengzhou People's Hospital from January 2020 to January 2022 were selected for standardized treatment for 6 courses.The clinical efficacy of the patients was observed,and the serum levels of sST2,RF,CCP antibodies and conventional efficacy indicators[C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),Chinese full name(DAS28)]were compared before and after treatment.The correlation between serum sST2,RF,CCP antibodies and clinical efficacy,as well as various conventional efficacy indicators was analyzed.Results The total effective rate of 72 patients after treatment was 91.67%;After treatment,the serum levels of sST2,RF,CCP antibody,DAS28 score,ESR,CRP in patients were lower than those before treatment,and the differences were statistically significant(P<0.05);The correlation analysis results showed that the serum levels of sST2,RF,CCP antibodies in patients were positively correlated with clinical efficacy,as well as with conventional efficacy indicators DAS28,ESR,and CRP.Conclusion There is a clear correlation between serum sST2,RF,CCP antibodies and RA efficacy,which can provide reference for the evaluation of RA efficacy.

关 键 词：类风湿性关节炎 可溶性基质裂解素2 类风湿因子 抗环瓜氨酸肽 

分 类 号：R684.3[医药卫生—骨科学]