血清IL-33、sP-SLT与心房颤动患者认知功能改变的关系  

The Relationship between Serum IL-33,sP-SLT and Cognitive Function Changes in Patients with Atrial Fibrillation

作　　者：王晓元[1] 杜美玲[1] 易梦阳 谭俊辉 李方江[1] 张爱爱[1] WANG Xiaoyuan;DU Meiling;YI Mengyang(Department of Cardiology,First Affiliated Hospital,Northern College,Hebei 075000,China)

机构地区：[1]河北北方学院附属第一医院心血管内科,张家口075000

出　　处：《医学研究杂志》2023年第5期115-118,129,共5页Journal of Medical Research

基　　金：河北省卫生和计划生育委员会科研基金资助项目(20170799);河北省张家口市级科技计划项目(2021087D)。

摘　　要：目的探究血清白细胞介素(interleukin,IL)-33、P-选择素(sP-SLT)表达水平与持续性心房颤动(atrial fibrillation,AF)患者认知功能障碍(cognitive impairment,CI)的关系。方法选取笔者医院2020年10月~2021年2月收治的160例AF患者,并采用蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评估其认知功能,将MoCA评分<26分者作为CI组(n=52)以及MoCA评分≥26分者作为NCI组(n=108),另选取同一时期体检健康者100例为对照组。所有受试者均于入院24h内采用双抗体夹心酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)测定其血清中IL-33、sP-SLT表达水平,并分析两者与MoCA总分及各分项评分的关系。结果CI组IL-33、sP-SLT水平较NCI组以及对照组均明显更高(P<0.01),且NCI组IL-33、sP-SLT水平亦较对照组明显更高(P<0.01);CI组I语言、记忆、抽象思维、执行功能、视结构技能、注意与集中、计算和定向力以及MoCA总分较NCI组以及对照组均明显更低(P<0.05);Pearson检验发现,认知功能障碍组患者血清IL-33、sP-SLT水平与语言、记忆、执行功能、视结构技能、注意与集中、计算和定向力以及MoCA总分均呈正相关(r分别为0.813、0.805、0.815、0.786、0.723、0.685、0.517;r分别为0.846、0.798、0.814、0.826、0.801、0.652、0.543,P均<0.001)。结论血清IL-33、sP-SLT水平与AF患者CI密切相关,有助于临床评估AF患者的认知功能。thinking,executive function,visual structure skills,attention and concentration,calculation and orientation and MoCA in CI group were significantly lower than those in NCI group and control group(P<0.05);Pearson correlation showed that the levels of serum IL-33 and sP-SLT in patients with cognitive impairment were positively correlated with language,memory,executive function,visual structure skills,attention and concentration,calculation and orientation,and the total score of MoCA(r were 0.813,0.805,0.815,0.786,0.723,0.685,0.517;r were 0.846,0.798,0.814,0.826,0.801,0.652,0.543,all P<0.001).Conclusion The levels of serum IL-33 and sP-SLT are closely related to CI in patients with AF,which is helpful to evaluate the cognitive function in patients with AF.

关 键 词：持续性心房颤动 白细胞介素-33 P-选择素 认知功能障碍 相关性 

分 类 号：R541[医药卫生—心血管疾病]