生物可降解塑料单体二元羧酸的生物合成研究进展  

Recent progress in the biosynthesis of dicarboxylic acids,a monomer of biodegradable plastics

作　　者：支睿 卢艳波 王敏 李国辉 邓禹 ZHI Rui;LU Yanbo;WANG Min;LI Guohui;DENG Yu(National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing,Jiangnan University,Wuxi 214122,Jiangsu,China;Shandong Provincial Key Laboratory of Fat&Oil Deep-Processing,Shandong Bohi Industry Co.,Ltd.,Binzhou 256500,Shandong,China;School of Biotechnology,Jiangnan University,Wuxi 214122,Jiangsu,China)

机构地区：[1]江南大学,粮食发酵与食品生物制造国家工程研究中心,江苏无锡214122 [2]山东渤海实业集团有限公司,山东省油脂油料精深加工技术重点实验室,山东滨州256500 [3]江南大学生物工程学院,江苏无锡214122

出　　处：《生物工程学报》2023年第5期2081-2094,共14页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(22008088,21877053);中国博士后科学基金资助项目(2020M681485,2021T140277);江苏省博士后科研资助计划(2020Z012)。

摘　　要：塑料是最重要的聚合物材料之一,需求量巨大,但存在处理困难、污染大等缺点。环境友好型的生物可降解塑料有望成为目前塑料的替代品,以满足社会各界对于塑料制品日益增长的需求。二元羧酸是生物可降解塑料中重要的单体之一,可降解性强,应用广泛,并且可以通过全生物法合成。因此,本文重点选取了几种比较有代表性的二元羧酸,总结它们的生物合成途径以及其代谢改造手段,以期为中长链等复杂二元羧酸的生物法合成提供借鉴。Plastics are one of the most important polymers with huge global demand.However,the downsides of this polymer are that it is difficult to degrade,which causes huge pollution.The environmental-friendly bio-degradable plastics therefore could be an alternative and eventually fulfill the ever-growing demand from every aspect of the society.One of the building blocks of bio-degradable plastics is dicarboxylic acids,which have excellent biodegradability and numerous industrial applications.More importantly,dicarboxylic acid can be biologically synthesized.Herein,this review discusses the recent advance on the biosynthesis routes and metabolic engineering strategies of some of the typical dicarboxylic acids,in hope that it will help to provide inspiration to further efforts on the biosynthesis of dicarboxylic acids.

关 键 词：生物可降解塑料 二元羧酸 代谢工程 

分 类 号：TQ225.14[化学工程—有机化工]