Nanomaterials disrupting cell-cell junctions towards various diseases  

作　　者：Shanbin Xu Xinlong Pang Xinyu Zhang Qian Lv Meng Zhang Jinping Wang Nengyi Ni Xiao Sun 

机构地区：[1]School of Chemistry and Pharmaceutical Engineering,Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250000,China [2]Institute of Surface Analysis and Chemical Biology,University of Jinan,Jinan 250022,China [3]Department of Chemical and Biomolecular Engineering,National University of Singapore,Singapore 117585,Singapore

出　　处：《Nano Research》2023年第5期7053-7074,共22页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22104073 and 22004048);the Natural Science Foundation of Shandong Province of China(Nos.ZR2021QB119,2022HWYQ-079,and ZR2020QB171);the Youth Innovation Science and Technology Program of Shandong Provincial Universities(No.2021KJ100).

摘　　要：As the continuous development of the industrial revolution,nanomaterials with excellent characteristics have been widely applied in various fields,greatly increasing the probability of human exposure to nanomaterials and the concerns about the potential nanotoxicity.Existing studies have shown that the toxicity of nanomaterials may be closely related to oxidative stress,inflammatory response,phagocytosis dysfunction,DNA damage,etc.Based on our focus,nanomaterials may cross the human barrier through various channels and disrupt various cell-cell junctions,while the integrity of cellular barrier is a necessary for the normal physiological function of various organs.However,until now,there is still a lack of systematic discussion in this field.This review illustrates the importance of cell-cell junctions in maintaining various organ functions and highlights the mechanism of various nanomaterials disrupt cell-cell junctions,as well as the possible damage to various organs,such as brain,eye,lung,breast,intestine,placenta,testis,heart,liver,kidney,skin,etc.Awareness of the potential negative effects of nanomaterials will help scientists deeply understand the limitations of nanotechnology,inspiring them to develop safer and more efficient nanomaterials for future personalized nanomedicine.

关 键 词：NANOMATERIALS NANOTOXICITY cell-cell junctions organ damage 

分 类 号：TB383[一般工业技术—材料科学与工程]