Biocompatible carbon nitride quantum dots nanozymes with high nitrogen vacancies enhance peroxidase-like activity for broadspectrum antibacterial  

作　　者：Xiaohui Dai Huan Liu Wenxiao Du Jie Su Lingshuai Kong Shouqing Ni Jinhua Zhan 

机构地区：[1]Key Laboratory of Colloid and Interface Chemistry,Ministry of Education,School of Chemistry and Chemical Engineering,State Key Laboratory of Crystal Materials,Shandong University,Jinan 250100,China [2]School of Environmental Science and Engineering,Shandong University,Jinan 250100,China [3]Institute of Eco-Environmental Forensics,Shandong University,Qingdao 266237,China

出　　处：《Nano Research》2023年第5期7237-7247,共11页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21876099,22106088,and 22276110);Key Research&Developmental Program of Shandong Province(No.2021CXGC011202);Fundamental Research Funds of Shandong University(No.zy202102).

摘　　要：Nanozyme antibacterial agents with high enzyme-like catalytic activity and strong bacteria-binding ability have provided an alternative method to efficiently disinfect drug-resistance microorganism.Herein,the carbon nitride quantum dots(CNQDs)nanozymes with high nitrogen vacancies(NVs)were mass-productively prepared by a simple ultrasonic-crushing method assisted by propylene glycol.It was found that the NVs of CNQDs were stemmed from the selective breaking of surface N-(C)_(2)sites,accounting for 6.2%.Experiments and density functional theory(DFT)simulations have demonstrated that the presence of NVs can alter the local electron distribution and extend theπ-electron delocalization to enhance the peroxidase-like activity.Biocompatible CNQDs could enter inside microorganisms by diffusion and elevate the bacteria-binding ability,which enhanced the accurate and rapid attack of·OH to the microorganisms.The sterilization rate of CNQDs against Gram-negative bacteria(E.coli),Gram-positive bacteria(S.aureus,B.subtilis),fungi(R.solani)reaches more than 99%.Thus,this work showed great potential for engineered nanozymes for broad-spectrum antibacterial in biomedicine and environmental protection.

关 键 词：carbon nitride quantum dots(CNQDs) nitrogen vacancies(NVs) peroxidase-like activity BIOCOMPATIBLE broad-spectrum antibacterial 

分 类 号：O64[理学—物理化学]