An ultra-sensitive metasurface biosensor for instant cancer detection based on terahertz spectra  

作　　者：Peiliang Wang Jing Lou Yun Yu Lang Sun Lan Sun Guangyou Fang Chao Chang 

机构地区：[1]Aerospace Information Research Institute,Chinese Academy of Sciences,Beijing 100094,China [2]Innovation Laboratory of Terahertz Biophysics,National Innovation Institute of Defense Technology,Beijing 100071,China [3]The Key Laboratory of Electromagnetic Radiation and Sensing Technology,Chinese Academy of Sciences,Beijing 100190,China [4]School of Electronic,Electrical and Communication Engineering,University of Chinese Academy of Sciences,Beijing 100049,China [5]Air and Missile Defense College,Air Force Engineering University,Xi’an 710051,China [6]Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100007,China [7]School of Psychological and Cognitive Sciences,Beijing Key Laboratory of Behavior and Mental Health,Peking University,Beijing 100871,China [8]School of Life Science and Technology,Xi’an Jiaotong University,Xi’an 710049,China

出　　处：《Nano Research》2023年第5期7304-7311,共8页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.12225511,T2241002,and 61988102,)and XPLORER PRIZE of C.C.

摘　　要：Metasurface biosensors have become the core label-free and rapid-detection technology in bioanalysis.Lung cancer and brain cancer are the first leading causes of cancer death among adults and adolescents,respectively,where poor early diagnosis results from expensive detection costs and time consumption.To tackle the above problems,here,we introduce a terahertzdomain metasurface biosensor for cancer diagnosis,relying on a perfectly symmetrical periodic surface structure,which significantly exhibits polarization-insensitivity at 2.05 THz and the high-sensitivity of 504 GHz/RIU(RIU=refractive index unit).According to the frequency shifts and transmittance variations,four cell types are successfully distinguished from each other.The minimum number of cells is required for thousands of cells to display the differences of spectra,which is 1/30 of clinical methods.Furthermore,the results were consistent with pathological results(the gold standard in clinic)by Gaussian curve fitting.The proposed biosensor has really achieved the characterization of cells in normal and cancerous state.This detection strategy dramatically reduced the cost of detection by reuse and time consumption was reduced to 1/20 of the pathology testing.In addition,it is flexible to set samples and easy to realize automatic operation due to the great polarization-insensitivity of the proposed biosensor,which can further reduce labor costs in the future.It is envisioned that the proposed biosensor will present immense potential in the fields of cancer detection,distinguishing different cancers,identifying primary lesion cancer or metastatic cancer.

关 键 词：TERAHERTZ metasurface BIOSENSOR cancer detection 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]