Metalloprotein-inspired supramolecular photodynamic nanodrugs by multicomponent coordination for deep penetration and enhanced biofilm eradication  

作　　者：Zhuo-Ran Yang Jingyi Xiong Sirui Wei Kehan Du Huimin Qin Teng Ma Niannian Lv Xinyu Yu Hao Jiang Jintao Zhu 

机构地区：[1]Hubei Engineering Research Center for Biomaterials and Medical Protective Materials,School of Chemistry and Chemical Engineering,Huazhong University of Science and Technology,Wuhan 430074,China [2]Department of Neurosurgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China

出　　处：《Nano Research》2023年第5期7312-7322,共11页纳米研究（英文版）

基　　金：the National Natural Science Foundation of China(No.52173124);the Fundamental Research Funds for the Central Universities(No.2172019kfyXJJS070).

摘　　要：Bacterial infections exacerbate the formation of bacterial biofilms,leading to resistance to traditional drugs,persistent infection,and even threatening patient’s life.Efficient antimicrobial materials against drug-resistant bacterial biofilms are highly desired.In this study,a photodynamic nanodrug with bacterial targeting was constructed by cooperative coordination of zinc ion with an antimicrobial peptide with hydrophobic tripeptides on the side chains and the photosensitizer chlorin e6.The supramolecular nanodrug with a uniform spherical structure possessed high photosensitizer loading capacity and enhanced photodynamic efficacy,which could deep penetrate and eradicate methicillin-resistant Staphylococcus aureus(MRSA)biofilms upon 655 nm laser irradiation.Furthermore,in vivo experiments verified the efficient elimination of MRSA biofilms on implanted catheters.This study provides a novel strategy to fabricate metalloprotein-inspired supramolecular photodynamic nanodrugs against drugresistant bacterial biofilms-associated infections in vivo.

关 键 词：photodynamic therapy supramolecular assembly COORDINATION deep penetration biofilm eradication 

分 类 号：R44[医药卫生—诊断学]