Nicotinamide adenine dinucleotide(NAD^(+))reduction enabled by an atomically precise Au-Ag alloy nanocluster  

作　　者：Ling Chen Yonglei Du Ying Lv Daoqing Fan Junfei Wu Lingbao Wu Mengting Cui Haizhu Yu Manzhou Zhu 

机构地区：[1]Department of Chemistry and Centre for Atomic Engineering of Advanced Materials,Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials,Anhui University,Hefei 230601,China [2]Institute of Energy,Hefei Comprehensive National Science Center,Hefei 230601,China

出　　处：《Nano Research》2023年第5期7770-7776,共7页纳米研究（英文版）

基　　金：National Science Foundation of Anhui Province(No.2108085J08);the University Synergy Innovation Program of Anhui Province(No.GXXT-2021-023);the technical support of high-performance computing platform of Anhui University.

摘　　要：The redox property of the ultrasmall coinage nanoclusters(with several to tens of Au/Ag atoms)has elucidated the electrontransfer capacity of nanoclusters,has been successfully utilized in a variety of redox conversions(such as from CO_(2)to CO).Nevertheless,their biological applications are mainly restricted by the scarcity of atomically precise,water-soluble metal nanoclusters,the limited application(mainly on the decomposition of H_(2)O_(2)in these days).Herein,mercaptosuccinic acid(MSA)protected ultrasmall alloy AuAg nanoclusters were prepared,the main product was determined[Au_(3)Ag_(5)(MSA)_(3)]−by electrospray ionization mass spectrometry(ESI-MS).The clusters can not only mediate the decomposition of H_(2)O_(2)to generate hydroxyl radicals,but is also able to mediate the reduction of nicotinamide adenine dinucleotide(NAD)to its reduced form of NADH.This is the first time that the atomically precise metal nanoclusters were used to mediate the coenzyme reduction.The preliminary mechanistic insights imply the reaction to be driven by the hydrogen bonding between the carboxylic groups(on the surface of MSA)and the amino N–H bonds(on NAD).In this context,the presence of the carboxylic groups,the sub-nanometer size regime(~1 nm),the synergistic effect of the Au-Ag clusters are pre-requisite to the NAD reduction.

关 键 词：redox-activity alloy AuAg nanocluster nicotinamide adenine dinucleotide(NAD)reduction synergistic effect size-effect 

分 类 号：O62[理学—有机化学]