蠕虫及其来源分子对螨性哮喘免疫调控的研究进展  

Research advances of the immune regulation of helminths and their derived molecules on mite-induced asthma

作　　者：李文杰 冯萌 程训佳[1] LI Wenjie;FENG Meng;CHENG Xunjia(Shanghai Medical College,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学上海医学院基础医学院,上海200032

出　　处：《中国寄生虫学与寄生虫病杂志》2023年第2期131-136,共6页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然基金面上项目(81572020)。

摘　　要：随着人们生活卫生水平的提高,我国寄生蠕虫的感染率显著下降,逐渐进入后寄生虫时代。但是与此同时,螨性哮喘的发病率逐年上升,造成了重大的社会经济负担。越来越多的证据表明,蠕虫感染与过敏性疾病之间存在一定的联系。本文对蠕虫及其来源分子对螨性哮喘免疫调控的研究进行综述,包括对抗原递呈细胞、B细胞、T细胞的免疫应答和细胞因子释放的直接调节作用以及蠕虫通过肠道微生物菌群的间接调节作用,为螨性哮喘的治疗提供新的思路与方向。The patient,a 46-year-old male,was a farmer from Zhongning County,Zhongwei City,Ningxia.The patient worked as a Gogie berry farmer and picker in Sidaogou Village,Yumen City,Jiuquan City,Gansu Province during 2013—2021 March to October.The patient showed fever,sweating and joint pain with no obvious causes on February 18,2022.The highest body temperature exceeded 40℃and the patient was diagnosed with a“lung infection”at a local clinic.Penicillin and cephalosporin were administrated but unsuccessful.On March 6,the patient was treated at the General Hospital of Ningxia Medical University.The patient’s physical examination upon admission showed clear consciousness,a flat and soft abdomen,no palpable abdominal mass,and no palpable subcostal liver.Blood routine showed:white blood cell count was 2.61×109/L,hemoglobin level was 122.0 g/L,platelet count was 114.0×109/L.On March 17,abdominal ultrasound showed liver enlargement,reduced and uniform echo in the paren-chyma,and unclear vascular imaging.Spleen enlargement without obvious lesions.On March 21,blood samples were sent to Yugok Biotechnology Co.Ltd.for the second-generation sequencing of the macro genome.The results showed 420 sequences of the Leishmania genus,including 418 sequences of L.donovani.Based on the clinical symptoms and laboratory examination results,it was diagnosed as visceral leishmaniasis.Amphotericin B(5 mg)was administered intravenously for 8 consecutive days,and the condition improved.The body temperature dropped to 36.2℃.On day 9,she was discharged after 1 day of intravenous drip with antimony sodium gluconate(6 ml).After discharge,the patient was given an intramuscular injection of antimony sodium gluconate(6 ml/d,suspended for 2 weeks after continuous injection for 6 days,and continued for 9 days),and other symptoms were treated accordingly.After one month of discharge,there was a phone follow-up,and the body felt light and weak;two months after discharge,the telephone follow-up showed good recovery.

关 键 词：蠕虫 蠕虫分子 免疫调节 螨性哮喘 

分 类 号：R531.6[医药卫生—内科学]