中性粒细胞胞外诱捕网在寄生虫感染中的作用和机制研究进展  

Research advances on the role and mechanism of neutrophil extracellular traps in parasitic infection

作　　者：黎嫦 杜新月 严敏 王兆军 LI Chang;DU Xinyue;YAN Min;WANG Zhaojun(Department of Immunology and Microbiology,Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;School of Global Health,Chinese Center for Tropical Diseases Research,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Department of Microbiology and Immunology,Kunming Medical University,Kunming 650500,Yunnan,Chin)

机构地区：[1]上海交通大学医学院免疫学与微生物学系,上海市免疫学研究所,上海200025 [2]上海交通大学医学院-国家热带病研究中心全球健康学院,上海200025 [3]昆明医科大学基础医学院病原生物学与免疫学系,云南昆明650500

出　　处：《中国寄生虫学与寄生虫病杂志》2023年第2期219-222,共4页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金(NSF-81971486,82272362)。

摘　　要：中性粒细胞胞外诱捕网(NET)是中性粒细胞胞内染色质与颗粒蛋白结合后释放至胞外所形成的网状结构。研究表明,原虫和蠕虫等寄生虫感染可诱导NET形成,并在抗寄生虫的免疫防御与寄生虫感染引起的免疫病理中发挥重要作用。本文综述了NET在常见原虫和蠕虫感染中的形成机制及其作用的最新研究进展,旨在为寄生虫病预防与治疗提供新思路。Neutrophil extracellular traps(NETs)are neutrophil-derived extracellular net-like structures that are composed of chromatin and granule proteins.Initial reports demonstrated that the infection of parasites like protozoa and helminths could induce NETs formation,which plays important roles in the immune defence against parasites and immunopathology caused by infection.This review described the mechanisms of NETs formation and the role of NETs in protozoan and helminth infection,which provides new ideas for the prevention and treatment of parasitic diseases.

关 键 词：中性粒细胞 中性粒细胞胞外诱捕网 原虫感染 蠕虫感染 

分 类 号：R382[医药卫生—医学寄生虫学] R383[医药卫生—基础医学]