外科止血粉的微观结构分析与止血性能研究  

Microstructure and performance analysis of surgical hemostatic powders

作　　者：舍浪浪 毛琳 宋成利[1] She Langlang;Mao Lin;Song Chengli(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093

出　　处：《国际生物医学工程杂志》2022年第6期503-507,共5页International Journal of Biomedical Engineering

基　　金：国家自然科学基金项目(51735003);上海理工大学医工交叉基金。

摘　　要：目的分析常用外科止血粉的微观结构,并对其止血性能进行研究。方法使用扫描电镜观察7种常用外科止血粉的微观结构,进行粒径测试分析,然后通过体外促凝血实验和家兔肝脏止血实验评估7种常用外科止血粉的止血性能。结果阿里斯泰止血粉的平均粒径为45.143μm,其颗粒表面存在很多凹槽,比表面积增大。体外促凝血实验表明,艾微停的吸光度和凝血指数最低,分别为0.03930±0.00603、3.42。家兔肝脏止血实验表明,实验组止血粉材料的止血效果明显优于对照组(均P<0.001),其中艾微停和阿里斯泰的效果较好,其止血时间分别是(44±17)、(48±9)s,有效出血量分别是(63±19)、(73±18)mg,与对照组比较,其差异均有统计学意义(均P<0.05)。结论阿里斯泰止血粉颗粒表面有很多凹槽,止血性能较好,艾微停的吸光度和凝血指数较低,止血性能也较好。Objective To analyze the microstructure of commonly used surgical hemostatic powders and investigate their hemostatic properties.Methods The microstructures of seven commonly used surgical hemostatic powders were observed by scanning electron microscopy and analyzed by particle size testing,and then the hemostatic properties of the seven commonly used surgical hemostatic powders were evaluated by an in vitro coagulation promotion test and a rabbit liver bleeding model.Results The average particle size of Aristide hemostatic powder was 45.143μm,and there were many grooves on the surface of the particles with increased specific surface area.The results of in vitro coagulation promotion tests showed that the absorbance and coagulation index of Aviagen were the lowest,which were 0.03930±0.00603 and 3.42,respectively.The rabbit liver bleeding experiment showed that the hemostatic effect of hemostatic powder materials in the experimental group was better than that in the control group(all P<0.001),among which Aviagen and Aristide were more effective.The hemostatic time and the effective bleeding volume of the experimental group and the control group were(44±17)s and(48±9)s,and(63±19)mg and(73±18)mg,respectively,and the differences were statistically significant(all P<0.05).Conclusions There are many grooves on the surface of Arista granules,which gives them a better performance in homeostasis in surgical applications.Avitene has lower absorbance and coagulation index,and better hemostatic properties.

关 键 词：止血粉 微观结构 止血性能 凝血指数 

分 类 号：R965[医药卫生—药理学]