强直性脊柱炎的免疫学研究进展  

Research progress in immunology of ankylosing spondylitis

作　　者：赵琳茹 孔纯玉[1] 李媛[1] 龚宝琪[1] Zhao Linru;Kong Chunyu;Li Yuan;Gong Baoqi(Department of Rheumatology and Immunology,Tianjin First Central Hospital,Tianjin 300192,China)

机构地区：[1]天津市第一中心医院风湿免疫科,天津300192

出　　处：《国际生物医学工程杂志》2022年第6期553-557,567,共6页International Journal of Biomedical Engineering

摘　　要：强直性脊柱炎(AS)是以骶髂关节和脊柱附着点炎症为特征的慢性炎症性疾病,是脊柱关节病最常见的类型。骨细胞与免疫细胞相互作用,分泌一系列的炎症因子,共同调控AS的发病。AS中各种免疫细胞的失调、炎症细胞因子的改变导致骨代谢紊乱,同时骨细胞表达各种炎症细胞因子,导致免疫系统失调。免疫系统与骨骼系统的相互作用已成为AS发病机制研究的热点,了解AS的骨免疫学机制将有助于更好地了解AS的确切发病机制并探索AS的新治疗方法。综述了AS中免疫细胞和炎症细胞因子的改变及其对骨骼系统的影响,以及骨骼系统中各种骨细胞的改变及其对免疫系统的影响,同时总结了AS的治疗进展。Ankylosing spondylitis(AS)is a chronic inflammatory disease characterized by inflammation of the sacroiliac joints and the spinal attachment point and is the most common type of spondyloarthritis(SpA).The pathogenesis of AS is related to both the immune system and the skeletal system.The main pathological changes include enthesitis,osteogenesis changes,osteolytic bone destruction,and immune system changes.Bone cells interact with immune cells,secrete a series of inflammatory factors,and jointly regulate the pathogenesis of AS.The imbalance of various immune cells in AS and the changes in inflammatory cytokines lead to a disorder of bone metabolism.At the same time,the osteocytes express various inflammatory cytokines,which leads to an imbalance of the immune system.The interaction between the immune system and the skeletal system has become a hot spot in the pathogenesis of AS.Understanding the bone immunological mechanism of AS will help to understand the exact pathogenesis of the disease and explore new treatment methods for it.In this review,the changes of various immune cells and inflammatory cytokines in AS and their effects on the skeletal system,as well as the changes of various osteocytes in the skeletal system and their effects on the immune system,were reviewed,and the latest progress in the treatment of AS was summarized.

关 键 词：强直性脊柱炎 免疫系统 骨骼系统 

分 类 号：R593.23[医药卫生—内科学]