甘油三酯-葡萄糖指数对中青年急性心肌梗死患者PCI术后预后的评估价值  

Value of triglyceride-glucose index in predicting prognosis of young and middle-aged patients with acute myocardial infarction after PCI

作　　者：赵江涛[1,2,3] 秦臻 于凤仪 王泽禹 高佳敏 朱揆 唐俊楠[1,2,3] 张金盈 ZHAO Jiangtao;QIN Zhen;YU Fengyi;WANG Zeyu;GAO Jiamin;ZHU Kui;TANG Junnan;ZHANG Jinying(Department of Cardiology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Henan Province′s Key Laboratory of Cardiac Injury and Repair,Zhengzhou 450052;Henan Cardiovascular Disease Clinical Medical Research Center,Zhengzhou 450052)

机构地区：[1]郑州大学第一附属医院心血管内科,郑州450052 [2]河南省心脏损伤修复重点实验室,郑州450052 [3]河南省心血管疾病临床医学研究中心,郑州450052

出　　处：《郑州大学学报（医学版）》2023年第3期337-341,共5页Journal of Zhengzhou University(Medical Sciences)

基　　金：国家自然科学基金面上项目(82170281);苏州工业园区心馨心血管健康基金会、中国心血管健康联盟进阶基金项目(2021-CCA-ACCESS-125)。

摘　　要：目的:探讨甘油三酯-葡萄糖(TyG)指数对中青年急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后的预后评估价值。方法:收集2012年1月至2020年1月就诊于郑州大学第一附属医院并接受PCI术的366例中青年AMI患者,术后中位随访时间为47(13~60)个月。终点事件为主要不良心血管事件(MACE),包括心源性死亡、再发心肌梗死、心血管疾病再入院、靶血管重建。通过计算约登指数得到TyG指数截断值。比较低TyG指数和高TyG指数组患者基线资料。采用Cox回归分析评估TyG指数对中青年AMI患者PCI术后的预后评估价值。根据Kaplan-Meier法进行生存分析。结果:随访期间发生MACE 161例。Cox回归分析显示,TyG指数升高是中青年AMI患者PCI术后发生MACE的危险因素(HR=2.871,95%CI 1.726~4.775,P<0.001)。结论:TyG指数升高是中青年AMI患者PCI术后发生MACE的危险因素。Aim:To evaluate the value of triglyceride-glucose(TyG)index in predicting prognosis in young and middle-aged acute myocardial infarction(AMI)patients after percutaneous coronary intervention(PCI).Methods:A total of 366 young and middle-aged AMI patients who received PCI in the First Affiliated Hospital of Zhengzhou University from January 2012 to January 2020 were enrolled in this study,and the median follow-up time was 47(13 to 60)months.MACE was defined as the end point,including cardiac death,recurrent myocardial infarction,rehospitalization due to cardiovascular disease and target vessel reconstruction.Cut-off value was calculated based on Youden index.The differences betweens high-TyG index and low-TyG index groups were compared.Cox regression was used to assess the predictive value of TyG index.Kaplan-Meier curve was used for survival analysis.Results:There were 161 MACE happened during the follow-up.Cox regression proved that elevated TyG index was a risk factor of MACE in young and middle-aged AMI patients after PCI(HR=2.871,95%CI 1.726-4.775,P<0.001).Conclusion:Elevated TyG index is a risk factor for MACE in young and middle-aged AMI patients after PCI.

关 键 词：甘油三酯-葡萄糖指数 急性心肌梗死 中青年 经皮冠状动脉介入治疗 预后 

分 类 号：R541.4[医药卫生—心血管疾病]