^(18)F-FDG PET/CT在原发性骨肉瘤患者预后评估中的价值  

Value of^(18)F-FDG PET/CT in the prognostic evaluation of primary osteosarcoma

作　　者：王心宇 陈平 杨萌 王庆祝[1] WANG Xinyu;CHEN Ping;YANG Meng;WANG Qingzhu(Department of Nuclear Medicine,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052)

机构地区：[1]郑州大学第一附属医院核医学科,郑州450052

出　　处：《郑州大学学报（医学版）》2023年第3期437-441,共5页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨^(18)F-FDG PET/CT在原发性骨肉瘤患者预后评估中的价值。方法:分析2014年4月至2021年10月在郑州大学第一附属医院于治疗前行^(18)F-FDG PET/CT显像的41例原发性骨肉瘤患者(男19例、女22例,中位年龄31岁),收集患者的临床特征及^(18)F-FDG PET/CT代谢参数,包括性别、年龄、身高、体重、肿瘤体积、CT值、肿瘤部位、治疗前是否转移、原发灶SUV_(max)值、全身肿瘤代谢体积之和(wbMTV)及全身总病灶糖酵解之和(wbTLG)(分别以40%SUV_(max)、SUV=2.5及SUV=2.0为阈值得到wbMTV40%、wbTLG40%、wbMTV2.5、wbTLG2.5、wbMTV2.0、wbTLG2.0),随访患者无进展生存期(PFS)。采用log-rank检验进行单因素生存分析,采用Cox比例风险模型进行多因素生存分析。结果:41例原发性骨肉瘤患者中,有17例患者复发或进展,有24例患者无转移,中位生存时间21个月。单因素分析结果显示,肿瘤体积、原发灶SUV_(max)、wbMTV40%、wbTLG40%、wbMTV2.5、wbTLG2.5、wbMTV2.0、wbTLG2.0均与患者PFS有关;多因素分析结果显示,原发灶SUV_(max)和wbTLG40%可评估原发性骨肉瘤患者的预后[HR(95%CI)分别为0.265(0.078~0.901)和0.193(0.051~0.729),P分别为0.033和0.015]。结论:原发灶SUV_(max)和wbTLG40%对评估原发性骨肉瘤患者的预后具有一定的参考价值。Aim:To investigate the value of ^(18)F-FDG positron emission tomography/computed tomography(PET/CT)in the prognostic evaluation of patients with primary osteosarcoma.Methods:A retrospective analysis of 41 patients(19 males and 22 females,median age 31 years)with primary osteosarcoma who underwent ^(18)F-FDG PET/CT imaging prior to treatment at the First Affiliated Hospital of Zhengzhou University between April 2014 and October 2021 was performed to collect clinical characteristics and ^(18)F-FDG PET/CT metabolic parameters,including gender,age,height,weight,tumor volume,CT value,tumor site,whether metastasis or not before treatment,primary foci SUV_(max) value of primary foci,sum of systemic tumor metabolic volume(wbMTV)and sum of systemic total lesion glycolysis(wbTLG)(using 40%SUV_(max),SUV=2.5 and SUV=2.0 as thresholds to obtain wbMTV40%,wbTLG40%,wbMTV2.5,wbTLG2.5,wbMTV2.0,wbTLG2.0),and progression-free survival(PFS)in follow-up patients.Log-rank test was used for single-factor survival analysis,and Cox proportional risk model was used for multi-factor survival analysis.Results:Among 41 patients with primary osteosarcoma,17 patients had recurrence or progression,and 24 patients were metastasis-free with a median survival time of 21 months.Single-factor analysis showed that tumor volume,primary foci SUV_(max),wbMTV40%,wbTLG40%,wbMTV2.5,wbTLG2.5,wbMTV2.0,and wbTLG2.0 were associated with PFS;the results of multi-factor analysis showed that primary foci SUV_(max) and wbTLG40%were evaluate prognosis of patients with primary osteosarcoma[HR(95%CI)was 0.265(0.078-0.901)and 0.193(0.051-0.729),P was 0.033 and 0.015].Conclusion:The primary foci SUV_(max) and wbTLG40%are informative in predicting the prognosis of patients with primary osteosarcoma.

关 键 词：原发性骨肉瘤 正电子发射断层显像术 脱氧葡萄糖 预后 

分 类 号：R814[医药卫生—影像医学与核医学]