寡肽转运蛋白PEPT1靶点的口服药物设计研究进展  

Study on oral drug design of oligopeptide transporter PEPT1 target

作　　者：胡珊 张文锍 孙勇兵 雷铭道[3] 胡律江 HU Shan;ZHANG Wenliu;SUN Yongbing;LEI Mingdao;HU Lvjiang(Jiangxi University of Chinese Medicine,Nanchang 330004,China;National Engineering Research Center for Solid Preparation Technology of Chinese Medicine,Jiangxi University of Chinese Medicine,Nanchang 330006,China;Department of Pharmacy,Jiangxi Maternal and Child Health Hospital,Nanchang 330006,China)

机构地区：[1]江西中医药大学药学院,江西南昌330004 [2]江西中医药大学中药固体制剂制造技术国家工程研究中心,江西南昌330006 [3]江西省妇幼保健院药学科,江西南昌330006

出　　处：《广东药科大学学报》2023年第3期131-136,共6页Journal of Guangdong Pharmaceutical University

基　　金：国家自然科学基金项目(81860630);江西省重点研发计划项目(20192ACB70012);江西中医药大学1050计划;南昌市重大科技攻关项目(2020-201-15)。

摘　　要：寡肽转运蛋白PEPT1在寡肽及拟肽类药物肠转运中发挥重要的作用,其能介导二肽或三肽类的吸收。PEPT1对底物识别的多专属性,使得以PEPT1为靶点设计载体前药提高药物吸收成为一种非常具有前景的策略。本文综述了有关肽转运蛋白PEPT1的生物学结构,及以PEPT1为靶点的前药最新研究进展,以期为后续对PEPT1的研究提供思路和参考。Peptide transporter PEPT1 played an important role in the transport of oligopeptides and peptide-like drugs across the small epithelial cell.PEPT1 has been a very attractive target to improve the oral absorption of drugs with low oral bioavailability by attaching a recognition group to the drug.In this paper,we reviewed the structure of PEPT1 and the recent progress of prodrugs targeting PEPT1,in order to provide ideas and reference for the further study of PEPT1.

关 键 词：PEPT1 前药 口服吸收 转运 结构 

分 类 号：R943[医药卫生—药剂学]