大剂量重组人红细胞生成素治疗尿毒症贫血的疗效观察  

High dose of rhEPO in treatment of uremic anemia

作　　者：吴俊[1] 袁志忠[1] 叶朝阳[1] 李玉斌[1] 孙琳琳[1] 梅长林[1] 

机构地区：[1]第二军医大学长征医院肾内科,解放军肾脏病中心上海200003

出　　处：《第二军医大学学报》2002年第11期1243-1245,共3页Academic Journal of Second Military Medical University

基　　金：上海市卫生系统百名跨世纪优秀学科带头人培养计划(97BR047).

摘　　要：目的:观察每周1次大剂量皮下注射国产重组人红细胞生成素(rhEPO)治疗尿毒症贫血的临床疗效。方法:20例尿毒症合并肾性贫血的血透患者,随机分为2组,试验组10例,采用国产rhEPO(益比奥,沈阳三生制药公司)10 000 U皮下注射1次/周治疗;对照组1O例,采用进口rhEPO(利血宝,日本麒麟公司)3 000 U皮下注射2～3次/周治疗。治疗期间,监测血常规、血脂、肝肾功能、电解质、血压等指标及患者出现的各种不良反应。结果:试验组显效5例、有效4例、无效1例;对照组显效6例、有效3例、无效1例,治疗前后白细胞、血小板、血脂、肝肾功能、电解质无明显变化。结论:大剂量益比奥每周1次治疗肾性贫血安全可靠、疗效确切,不良反应发生率与利血宝相似,且价格/药效明显低于利血宝。Objective: To evaluate the clinical effect of high dose of rhEPO on uremic anemia by subcutaneous injection once a week. Methods: Twenty anemic patients on maintenance hemodialysis were divided into 2 groups at random. Ten patients in treatment group accepted 10 000 U of rhEPO (Shenyang Sunshine Pharmaceutical Co. Ltd. ) through subcutaneous injection once a week. Ten patients in control group accepted 3 000 U of EPO (Kirin Kunpeng Bio-pharmaceutical Co. Ltd. ) through subcutaneous injection twice to 3 times a week. Routine blood test,liver and kidney function,electrolyte,blood pressure and side effects were observed. Results: The obvious effective,effective and ineffective cases in treatment group were 5, 4 and 1 respectively and 6,3 and 1 in control group respectively. The pre- and post-treatment liver and kidney function,electrolyte, blood pressure and side effects of the 2 groups had no significant changes. Conclusion: Treatment of uremic anemia with high dose of rhEPO is effective and safe. The side effect of rhEPO is similar in 2 groups. The cost/effect of rhEPO in treatment group is significantly lower than that in control group.

关 键 词：尿毒症 肾性贫血 重组人红细胞生成素 大剂量 治疗 

分 类 号：R556.9[医药卫生—血液循环系统疾病] R692.[医药卫生—内科学]