bFGF、TGF-β_1在体表海绵状静脉畸形中的表达及其意义  

Expression of bFGF and TGF-β_1 in cavernous venous malformation of body surface

作　　者：袁斯明[1] 欧阳天祥[1] 邢新[1] 倪灿荣[2] 郑唯强[2] 温萍[2] 

机构地区：[1]第二军医大学长海医院整形外科,上海200433 [2]长海医院病理科

出　　处：《第二军医大学学报》2002年第11期1246-1248,共3页Academic Journal of Second Military Medical University

基　　金：长海医院"123"人才基金项目(99360967).

摘　　要：目的:研究bFGF、TGF-β1在体表海绵状静脉畸形中的表达及其意义。方法:体表海绵状静脉畸形标本25例,正常中、小静脉各12例。Envision法免疫组织化学染色观察bFGF、TGF-β1表达,半定量分析。结果:海绵状静脉畸形和正常中、小静脉中bFGF和TGF-β1表达都很微弱,无明显差别。毛细血管和毛细血管后微静脉的血管壁有较强TGF-β1表达,呈棕黄和棕黑色斑块状包绕管腔。结论:bFGF和TGF-β1分泌少可能不是体表海绵状静脉畸形始发原因,但与畸形病理结构形成有一定关系。Objective: To study the expression of bFGF and TGF-β1 in cavernous venous malformation of body surface. Methods: Envision immunohistochemical stain was used to detect the expression of bFGF and TGF-β1 in 25 cases of cavernous venous malformations, 12 cases of normal medium-sized veins and 12 cases of normal small veins, the results were analyzed semi-quantitatively. Results: Cavernous venous malformations,medium-sized veins and small veins all expressed bFGF and TGF-β1 weakly with no difference,but capillaries and postcapillary venules strongly expressed TGF-β1 with brown,yellow and black stain around the vessels. Conclusion: The weak expression of bFGF and TGF-β1 may not be the initial cause of cavernous venous malformation,but it may be related to the formation of pathologic structure.

关 键 词：静脉畸形 碱性成纤维细胞生长因子 转化生长因子Β1 免疫组织化学 

分 类 号：R543.6[医药卫生—心血管疾病]