主要协同转运蛋白超家族膜转运蛋白与细菌生物膜形成的相关性研究进展  

Research progress on the correlation of major facilitator superfamily membrane transporters and bacterial biofilm formation

作　　者：杨锐富 周燕斌[1] Yang Ruifu;Zhou Yanbin(Department of Pulmonary and Critical Care Medicine,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院呼吸与危重症医学科,广州510080

出　　处：《中华诊断学电子杂志》2023年第2期77-81,共5页Chinese Journal of Diagnostics(Electronic Edition)

基　　金：国家自然科学基金面上项目(81570008);广东省自然科学基金面上项目(2021A1515010480)。

摘　　要：细菌生物膜的形成是一个多因素参与、动态有序的过程,可引起多种慢性细菌感染。主要协同转运蛋白超家族(MFS)是目前已知最大的膜转运蛋白超家族之一,同时也是细菌六大外排泵家族之一。目前研究发现,MFS膜转运蛋白与细菌生物膜形成密切相关,前者对细菌生物膜形成的影响主要涉及包括生物膜基质组分在内的多种底物转运、诱导合成以及生物膜形成的代谢过程3个方面。笔者就MFS膜转运蛋白的概念、结构功能、转运机制及其影响细菌生物膜形成的可能机制进行综述,以期为细菌生物膜相关研究提供理论依据。The dynamic and ordered process of bacterial biofilm production,which involves numerous components,can cause a variety of chronic illnesses.Major facilitator superfamily(MFS),one of the six bacterial efflux pump families,is one of the largest superfamilies of membrane transport proteins.Recent studies have revealed a close connection between the MFS membrane transporters and the formation of bacterial biofilm.The former has the greatest influence on biofilm formation due to three factors:the transport of substrates containing biofilm matrix components,the induction of biofilm matrix component synthesis,and the metabolic process of biofilm formation.In this review,the concept and transport mechanism of MFS membrane transporters,and their possible mechanisms affecting the formation of bacterial biofilm are summarized to provide a theoretical basis for related research on bacterial biofilm.

关 键 词：主要协同转运蛋白超家族 细菌 生物膜形成 相关性 

分 类 号：Q51[生物学—生物化学]