Effect of maternal pregestational diabetes mellitus on congenital heart diseases  

作　　者：Zhi-Yan Chen Shuang-Fa Mao Ling-Hong Guo Jian Qin Li-Xin Yang Yin Liu 

机构地区：[1]Department of Basic Medical Sciences,Sichuan Vocational College of Health and Rehabilitation,Zigong,643000,China [2]Department of Pharmacology,West China School of Basic Sciences and Forensic Medicine,Sichuan University,Chengdu,610041,China [3]Department of Anesthesiology,Sichuan Cancer Hospital and Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu,610000,China [4]Animal Research Institute,Sichuan University,Chengdu,China

出　　处：《World Journal of Pediatrics》2023年第4期303-314,共12页世界儿科杂志（英文版）

基　　金：supported by Sichuan Vocational College of Health and Rehabilitation(No.CWKY-2020Z-02);the Department of Science and Technology of Sichuan Province(No.2019YJ0079);the National Natural Science Foundation of China(No.81900283).

摘　　要：Background The increasing population of diabetes mellitus in adolescent girls and women of childbearing age contributes to a large number of pregnancies with maternal pregestational diabetes mellitus.Congenital heart diseases are a common adverse outcome in mothers with pregestational diabetes mellitus.However,there is little systematic information between maternal pregestational diabetes mellitus and congenital heart diseases in the offspring.Data sources Literature selection was performed in PubMed.One hundred and seven papers were cited in our review,includ-ing 36 clinical studies,26 experimental studies,31 reviews,eight meta-analysis articles,and six of other types.Results Maternal pregestational diabetes mellitus poses a high risk of congenital heart diseases in the offspring and causes variety of phenotypes of congenital heart diseases.Factors such as persistent maternal hyperglycemia,oxidative stress,polymorphism of uncoupling protein 2,polymorphism of adiponectin gene,Notch 1 pathway,Nkx2.5 disorders,dysregula-tion of the hypoxia-inducible factor 1,and viral etiologies are associated with the occurrence of congenital heart diseases in the offspring of mothers with pregestational diabetes mellitus.Treatment options including blood sugar-reducing,anti-oxidative stress drug supplements and exercise can help to prevent maternal pregestational diabetes mellitus from inducing congenital heart diseases.Conclusions Our review contributes to a better understanding of the association between maternal pregestational diabetes mellitus and congenital heart diseases in the offspring and to a profound thought of the mechanism,preventive and therapeutic measurements of congenital heart diseases caused by maternal pregestational diabetes mellitus.

关 键 词：Congenital heart disease Maternal pregestational diabetes mellitus MECHANISM PREVENTION 

分 类 号：R714.256[医药卫生—妇产科学]