Effects of synbiotic supplementation on anthropometric indices and body composition in overweight or obese children and adolescents:a randomized,double-blind,placebo-controlled clinical trial  

作　　者：Mohammad Amin Atazadegan Motahar Heidari-Beni Mohammad Hassan Entezari Fariborz Sharifianjazi Roya Kelishadi 

机构地区：[1]Department of Clinical Nutrition,School of Nutrition and Food Sciences,Isfahan University of Medical Sciences,Isfahan,Iran [2]Department of Nutrition,Child Growth and Development Research Center,Research Institute for Primordial Prevention of Non-Communicable Disease,Isfahan University of Medical Sciences,Isfahan,Iran [3]Department of Clinical Nutrition,School of Nutrition and Food Science,Isfahan University of Medical Sciences,Isfahan,Iran [4]School of Science and Technology,The University of Georgia,Tbilisi,Georgia [5]Department of Pediatrics,Child Growth and Development Research Center,Research Institute for Primordial Prevention of Non-Communicable Disease,Isfahan University of Medical Sciences,Isfahan,Iran

出　　处：《World Journal of Pediatrics》2023年第4期356-365,共10页世界儿科杂志（英文版）

基　　金：conducted as the project number 298113 supported by Isfahan University of Medical Sciences.

摘　　要：Background Recently,beneficial effects of probiotics and/or prebiotics on cardio-metabolic risk factors in adults have been shown.However,existing evidence has not been fully established for pediatric age groups.This study aimed to assess the effect of synbiotic on anthropometric indices and body composition in overweight or obese children and adolescents.Methods This randomized double-blind,placebo-controlled trial was conducted among 60 participants aged 8-18 years with a body mass index(BMI)equal to or higher than the 85th percentile.Participants were randomly divided into two groups that received either a synbiotic capsule containing 6x109 colony forming units(CFU)Lactobacillus coagulans SC-208,6 x 109 CFU Lactobacillus indicus HU36 and fructooligosaccharide as a prebiotic(n=30)or a placebo(n=30)twice a day for eight weeks.Anthropometric indices and body composition were measured at baseline and after the intervention.Results The mean(standard deviation,SD)age was 11.07(2.00)years and 11.23(2.37)years for the placebo and synbiotic groups,respectively(P=0.770).The waist-height ratio(WHtR)decreased significantly at the end of the intervention in comparison with baseline in the synbiotic group(0.54±0.05 vs.0.55±0.05,P=0.05).No significant changes were dem-onstrated in other anthropometric indices or body composition between groups.Conclusions Synbiotic supplementation might be associated with a reduction in WHtR.There were no significant changes in other anthropometric indices or body composition.

关 键 词：ANTHROPOMETRY Body composition Pediatrics SYNBIOTICS 

分 类 号：R725.7[医药卫生—儿科]