冠心宁片治疗老年人稳定型心绞痛临床疗效及对血栓前状态分子标志物的影响  

Clinical efficacy of the Guanxinning tablet for stable angina pectoris in the elderly and its effects on molecular markers of the prethrombotic state

作　　者：王俊 沈金龙 阮浩坤 王益波 孙国香 王东之 杨晓翠 Wang Jun;Shen Jinlong;Ruan Haokun;Wang Yibo;Sun Guoxiang;Wang Dongzhi;Yang Xiaocui(Department of Cardiovascular Medicine,Shaoxing Shangyu District Hospital of Traditional Chinese Medicine,Shaoxing 312300,China)

机构地区：[1]绍兴市上虞区中医医院心血管科,绍兴312300

出　　处：《中华老年医学杂志》2023年第5期515-518,共4页Chinese Journal of Geriatrics

基　　金：浙江省医学会临床基金科研项目(2019ZYC-A154)。

摘　　要：目的探讨冠心宁片改善老年稳定型心绞痛血栓前状态的临床疗效。方法选取医院2019年12月至2021年12月收治的80例老年冠心病心血瘀阻患者为研究对象,随机分为对照组和观察组(各40例),对照组单用阿司匹林肠溶片,观察组在对照组的基础上加用冠心宁片,比较两组患者中医证候积分、每周心绞痛发作次数及每次发作持续时间、血管性血友病因子(vWF)、血浆血栓调节蛋白(TM)、血浆血小板α颗粒膜蛋白(GMP-140)等分子水平的差异。结果治疗前观察组和对照组中医证候积分比差异无统计学意义[(11.3±2.2)分和(11.8±2.3)分,t=0.184,P=0.856],治疗后观察组和对照组比差异有统计学意义[(6.5±1.8)分和(8.4±2.0)分,t=4.230,P=0.000];观察组每周心绞痛发作次数及每次发作持续时间较对照组均下降,差异具有统计学意义(均P<0.01)。观察组血栓前状态分子标志物(vWF、TM、GMP-140)均优于对照组(均P<0.05)。结论冠心宁片能改善老年冠心病患者心绞痛症状,并有效改善血栓前状态分子标志物的表达。Objective To investigate the clinical efficacy of the Guanxinning tablet on the prethrombotic state in older adults with stable angina pectoris.Methods In this study,80 elderly patients with coronary heart disease and blood stasis admitted to our hospital between December 2019 and December 2021 were selected as the study subjects,and were randomly divided into a control group and an observation group(40 cases each).The control group was treated with Aspirin alone,and the observation group was treated with the Guanxinning tablet in addition to aspirin.Differences in traditional Chinese medicine(TCM)syndrome scores,weekly angina attacks and intervals between attacks,von Willebrand factor(vWF),thrombomodulin(TM),and granule membrane protein-140(GMP-140)levels between the two groups were compared.Results There was no statistically significant difference in TCM syndrome scores between the observation group and the control group before treatment(11.34±2.2 vs.11.8±2.3,t=0.184,P=0.856),but there was a statistically significant difference between the observation group and the control group after treatment(6.5±1.8 vs.8.4±2.0 points,t=4.230,P=0.000).The number of weekly angina attacks and the interval between attacks in the observation group were significantly decreased compared with the control group,and the difference was statistically significant(all P<0.01).The levels of molecular markers of the prethrombotic state(vWF,TM and GMP-140)in the observation group were more favorable than those in the control group,with statistical significance(all P<0.05).Conclusions The Guanxinning tablet can improve angina pectoris symptoms in elderly patients with coronary heart disease and effectively improve the expression of molecular markers of the prethrombotic state.

关 键 词：心绞痛 血栓调节蛋白 血栓前状态 

分 类 号：R259[医药卫生—中西医结合]