Ultrasound-driven BaTiO_(3) nanorobots patching immunologic barrier to cure chronic rheumatoid arthritis  

作　　者：Le Jiang Yifan Wang Chunlin Liu Nan Xu Wenshuo Li Lei Wang Yixian Wu Jingyun Wang Zhijun He Fengbo Sun Lingyun Zhao Qiong Wu Xiumei Wang Huihui Yuan Xiaohui Wang Xiaodan Sun 

机构地区：[1]State Key Laboratory of New Ceramics and Fine Processing,School of Materials Science and Engineering,Tsinghua University,Beijing 100084,China [2]Key Laboratory of Advanced Materials of Ministry of Education of China,School of Materials Science and Engineering,Tsinghua University,Beijing 100084,China [3]MOE Key Lab.Bioinformatics,School of Life Sciences,Tsinghua University,Beijing 100084,China [4]Department of Immunology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China

出　　处：《Journal of Advanced Ceramics》2023年第5期1105-1117,共13页先进陶瓷（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(Grant Nos.52072210 and 52111530230);Key R&D Projects of Social Development of Hainan Provincial Department of Science and Technology(Grant No.ZDYF2020137);Tsinghua University Beijing Union Medical CollegeeHospital Cooperation Project(Grant No.20191080871).

摘　　要：The disruption and reconstruction of the TREM2^(+) tissue resident macrophage(TRM)barrier on the surface of synovial lining play a key role in the activation and"remission"of rheumatoid arthritis(RA),which engender the prediction of this immunologic barrier as a potential driver for the achievement of"cure"in RA.However,strategies to promote the reconstruction of this barrier have not been reported,and the effect of patching this barrier remains unidentified.On the other hand,appropriate piezoelectric stimulation can reprogram macrophages,which has never been exerted on this barrier TRM yet.Herein,we design piezoelectric tetragonal BaTiO_(3)(BTO)ultrasound-driven nanorobots(USNRs)by the solvothermal synthesis method,which demonstrates satisfactory electro-mechanical conversion effects,paving the way to generate controllable electrical stimulation under ultrasound to reprogram the barrier TRM by minimally invasive injection into joint cavity.It is demonstrated that the immunologic barrier could be patched by this USNR effectively,thereby eliminating the hyperplasia of vessels and nerves(HVN)and synovitis.Additionally,TREM2 deficiency serum-transfected arthritis(STA)mice models are applied and proved the indispensable role of TREM2 in RA curing mediated by USNR.In all,our work is an interesting and important exploration to expand the classical tetragonal BTO nanoparticles in the treatment of autoimmune diseases,providing a new idea and direction for the biomedical application of piezoelectric ceramics.

关 键 词：ultrasound-driven BaTiO_(3)nanorobots(BTO NRs) immunologic barrier upstream driver rheumatoid arthritis(RA) 

分 类 号：TB33[一般工业技术—材料科学与工程]