带状疱疹后神经痛动物模型制作的研究进展  

Progresses in the establishment of animal model of postherpetic neuralgia

作　　者：吴松斌 杨少敏 黄佳彬 孙武平 熊东林 肖礼祖 Wu Songbin;Yang Shaomin;Huang Jiabin;Sun Wuping;Xiong Donglin;Xiao Lizu(Department of Pain Medicine,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen Key Laboratory of Pain Medicine,Nanshan Hospital,Shenzhen City,Guangdong Province 518052,China)

机构地区：[1]华中科技大学协和深圳医院疼痛科深圳市疼痛学重点实验室,深圳市518052

出　　处：《中华疼痛学杂志》2023年第2期338-341,共4页Chinese Journal Of Painology

摘　　要：本文主要综述目前国内外带状疱疹后神经痛(PHN)动物模型制作的研究进展,重点介绍由水痘-带状疱疹病毒(VZV)与单纯疱疹病毒Ⅰ型(HSV1)诱发的PHN动物模型的建立方法和疼痛行为学表现。旨在比较现有PHN动物模型的研究概况,为进一步阐明PHN致病机制提供有效的研究工具,同时也为PHN动物模型的选择和改良提供参考。This review mainly introduced the research progresses in the establishment of postherpetic neuralgia(PHN)animal model at home and abroad,with emphasis on the establishment methods and pain behaviors of PHN animal model induced by varicella zoster virus(VZV)or herpes simplex virus 1(HSV1).The aims of this paper were to compare the current research status of PHN animal model,and to provide effective research tool for further elucidating the pathogenic mechanism of PHN,and reference for selecting and improving the PHN animal model.

关 键 词：神经痛 带状疱疹后 疾病模型 动物 水痘-带状疱疹病毒 单纯疱疹病毒Ⅰ型 

分 类 号：R752.12[医药卫生—皮肤病学与性病学] R-332[医药卫生—临床医学]