不同亚型慢性鼻窦炎与外周血嗜碱粒细胞的相关性研究  

Correlation between chronic sinusitis subtypes and basophil levels in peripheral blood

作　　者：范煜辉 焦晴晴[2] 周爱娜 刘济生[1] FAN Yuhui;JIAO Qingqing;ZHOU Aina;LIU Jisheng(Department of Otorhinolaryngology Head and Neck Surgery,the First Affiliated Hospital of Soochow University,Suzhou,215006,China;Department of Dermatology,the First Affiliated Hospital of Soochow University)

机构地区：[1]苏州大学附属第一医院耳鼻咽喉头颈外科,江苏苏州215006 [2]苏州大学附属第一医院皮肤性病科

出　　处：《临床耳鼻咽喉头颈外科杂志》2023年第4期293-296,301,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨外周血嗜碱粒细胞计数及相关比值与慢性鼻窦炎(CRS)的临床相关性。方法:回顾性分析2021年1月-2022年10月于苏州大学附属第一医院收治的126例CRS患者(CRS组)和103例健康体检者(对照组),根据组织学病理分为嗜酸性CRS患者(eCRS组)47例和非嗜酸性CRS患者(non-eCRS组)79例,比较3组外周血炎症细胞计数及嗜酸粒细胞/嗜碱粒细胞比值(eosinophils-to-basophils ratio,bEBR)、嗜碱粒细胞/中性粒细胞比值(basophils-to-neutrophils ratio,BNR)、嗜碱粒细胞/淋巴细胞比值(basophils-to-lymphocytes ratio,BLR)、嗜碱粒细胞/单核细胞比值(basophils-to-monocytes ratio,BMR)等之间的差异,并研究各项指标与Lund-Mackay评分的相关性,外周血中嗜碱粒细胞与其他炎症细胞的相关性。结果:对照组、eCRS组、non-eCRS组外周血嗜碱粒细胞计数分别为0.03±0.01、0.04±0.02、0.03±0.02,bEBR分别为5.64±4.22、8.38±5.95、4.55±3.90,BNR分别为0.01±0、0.01±0.01、0.01±0.01,BLR分别为0.01±0.01、0.02±0.01、0.02±0.01,BMR分别为0.08±0.04、0.11±0.06、0.08±0.04,3组间两两对比,eCRS组与对照组、non-eCRS组相比差异均有统计学意义(P<0.01),non-eCRS组与对照组相比,差异均无统计学意义(P>0.05)。CRS患者嗜碱粒细胞计数(r=0.1855,P<0.05)、BLR(r=0.2269,P<0.05)、BMR(r=0.2281,P<0.01)均与Lund-Mackay评分呈正相关。此外,CRS患者嗜碱粒细胞与嗜酸粒细胞(r=0.4792,P<0.01)、淋巴细胞(r=0.2594,P<0.01)、单核细胞(r=0.2564,P<0.01)亦显著呈正相关性。结论:外周血嗜碱粒细胞计数、BLR、BMR在eCRS中显著升高,且与Lund-Mackay评分呈显著正相关性,有潜力开发成为eCRS的疾病生物标记物及新的治疗靶点。Objective: To explore the clinical correlation between peripheral blood basophil levels and chronic sinusitis(CRS)subtypes.Methods: One hundred and twenty-six patients with CRS and 103 healthy cases from physical examination admitted to the First Affiliated Hospital of Soochow University from January 2021 to October 2022 were retrospectively analyzed.According to the histopathological classification,CRS patients were divided into eosinophilic chronic sinusitis(eCRS)group(47 cases)and non eosinophilic chronic sinusitis(non-eCRS)group(79 cases).The differences among the three groups in peripheral blood inflammation cell counts,eosinophils-to-basophils ratio(bEBR),basophils-to-neutrophils ratio(BNR),basophils-to-lymphocytes ratio(BLR),basophils-to-monocytes ratio(BMR)were compared,and study the correlation between each index and Lund-Mackay score,and the correlation between basophils in peripheral blood and other inflammatory cells.Results: The counts of basophils in the peripheral blood of the healthy control group,eCRS group and non-eCRS group were 0.03±0.01,0.04±0.02,0.03±0.02,respectively,the eosinophils-to-basophils ratio(bEBR)were 5.64±4.22,8.38±5.95,4.55±3.90,the basophils-to-neutrophils ratio(BNR)were 0.01±0,0.01±0.01,0.01±0.01,and the basophils-to-lymphocytes ratio(BLR)were 0.01±0.01,0.02±0.01,and 0.02±0.01,respectively,the basophils-to-monocytes ratio(BMR)were 0.08±0.04,0.11±0.06,and 0.08±0.04 respectively.There was a statistically significant difference between eCRS group and healthy control group,non-eCRS group(P<0.01),while there was no statistically significant difference between non-eCRS group and healthy control group(P>0.05).Basophil counts(r=0.1855,P<0.05),BLR(r=0.2269,P<0.05),BMR(r=0.2281,P<0.01)in patients with CRS were positively correlated with Lund Makey score.In addition,basophils were also positively correlated with eosinophils(r=0.4792,P<0.01),lymphocytes(r=0.2594,P<0.01),and monocytes(r=0.2564,P<0.01)in patients with CRS.Conclusion: The peripheral blood basophil count,BLR an

关 键 词：慢性鼻窦炎 嗜碱粒细胞 嗜酸粒细胞 淋巴细胞 单核细胞 

分 类 号：R765.41[医药卫生—耳鼻咽喉科]