甘草酸和甘草苷生物合成与调控的研究进展  

Research Progress in the Biosynthesis and Regulation of Glycyrrhizic Acid and Liquiritin

作　　者：周定定 李辉虎 汤兴涌 余发新[3] 孔丹宇 刘毅[2] ZHOU Ding-ding;LI Hui-hu;TANG Xing-yong;YU Fa-xin;KONG Dan-yu;LIU Yi(College of Life Science,Nanchang University,Nanchang 330031;Lushan Botanical Garden,Chinese Academy of Sciences,Jiujiang 332900;The Key Laboratory of Horticultural Plant Genetic and Improvement of Jiangxi Province,Institute of Biological Resources,Jiangxi Academy of Sciences,Nanchang 330096;Shanghai Xingyun Industrial Development,Shanghai 201613)

机构地区：[1]南昌大学生命科学学院,南昌330031 [2]中国科学院庐山植物园,九江332900 [3]江西省科学院生物资源研究所江西省观赏植物遗传改良重点实验室,南昌330096 [4]上海兴昀实业发展有限公司,上海201613

出　　处：《生物技术通报》2023年第5期44-53,共10页Biotechnology Bulletin

基　　金：中国科学院重点部署项目(KJZD-SW-L13);江西省人才项目(jxsq2020101020)。

摘　　要：甘草是一种被多个国家药典收录的常用中草药,由豆科甘草属特定物种的根和匍匐茎炮制而成。甘草含有丰富的次生代谢物和多种活性成分,具有抗肿瘤、抗菌、抗病毒、抗炎和增强免疫等多方疗效。甘草酸和甘草苷是甘草最重要的活性物质。近年来甘草酸和甘草苷的生物合成和调控的研究进展突出。为此,本文综述了甘草中甘草酸和甘草苷的生物合成途径,以及非生物胁迫、生物因素对合成通路调控的研究进展;也对甘草酸和甘草苷的生物合成及调控的未来研究提出展望,以期对该领域的未来发展带来一定帮助。Licorice(Gan-Cao)is a popular herbal medicine derived from the dried roots and stolons of special species in the genus Glycyrrhiza(Fabaceae)and is recorded in the pharmacopoeias of many countries.Various critical secondary metabolites provide licorice many important pharmaceutical activities,such as antitumor,antibacterial,anti-viral,anti-inflammatory,and immunostimulatory.Glycyrrhizic acid and liquiritin are the most important bioactive compounds in licorice.In recent years,the biosynthesis and regulation of glycyrrhizic acid and liquiritin in licorice have been well-studied.In this review,we introduce the biosynthetic pathways of glycyrrhizic acid and liquiritin,and summarize progress of the regulation of glycyrrhizic acid and liquiritin biosynthesis.At last,we propose future perspectives for studying the biosynthesis and regulation of glycyrrhizic acid and liquiritin in licorice.

关 键 词：甘草 生物合成 调控 甘草酸 甘草苷 

分 类 号：R28[医药卫生—中药学]